PMID- 11222144
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 128
IP  - 6
DP  - 2001 Mar
TI  - A role for the EphA family in the topographic targeting of vomeronasal axons.
PG  - 895-906
AB  - We have investigated the role of the Eph family of receptor tyrosine kinases and 
      their ligands in the establishment of the vomeronasal projection in the mouse. 
      Our data show intriguing differential expression patterns of ephrin-A5 on 
      vomeronasal axons and of EphA6 in the accessory olfactory bulb (AOB), such that 
      axons with high ligand concentration project onto regions of the AOB with high 
      receptor concentration and vice versa. These data suggest a mechanism for 
      development of this projection that is the opposite of the repellent interaction 
      between Eph receptors and ligands observed in other systems. In support of this 
      idea, when given the choice of whether to grow on lanes containing 
      EphA-F(c)/laminin or F(c)/laminin protein (in the stripe assay), vomeronasal 
      axons prefer to grow on EphA-F(c)/laminin. Analysis of ephrin-A5 mutant mice 
      revealed a disturbance of the topographic targeting of vomeronasal axons to the 
      AOB. In summary, these data, which are derived from in vitro and in vivo 
      experiments, indicate an important role of the EphA family in setting up the 
      vomeronasal projection.
FAU - Knoll, B
AU  - Knoll B
AD  - Department of Physical Biology, Max-Planck-Institute for Developmental Biology, 
      Spemannstrasse 35 / I, 72076 Tubingen, Germany.
FAU - Zarbalis, K
AU  - Zarbalis K
FAU - Wurst, W
AU  - Wurst W
FAU - Drescher, U
AU  - Drescher U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Laminin)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, EphA5)
RN  - EC 2.7.10.1 (Receptor, EphA7)
RN  - EC 3.2.1.23 (beta-Galactosidase)
SB  - IM
MH  - Animals
MH  - Axons/*physiology
MH  - Embryonic and Fetal Development/*physiology
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Laminin/genetics/physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Olfactory Bulb/*embryology
MH  - Olfactory Pathways/*embryology
MH  - Receptor Protein-Tyrosine Kinases/deficiency/genetics/*physiology
MH  - Receptor, EphA5
MH  - Receptor, EphA7
MH  - Vomeronasal Organ/cytology/*embryology
MH  - beta-Galactosidase/genetics
EDAT- 2001/02/27 10:00
MHDA- 2001/05/01 10:01
CRDT- 2001/02/27 10:00
PHST- 2001/02/27 10:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/02/27 10:00 [entrez]
AID - 10.1242/dev.128.6.895 [doi]
PST - ppublish
SO  - Development. 2001 Mar;128(6):895-906. doi: 10.1242/dev.128.6.895.