PMID- 11222965
OWN - NLM
STAT- MEDLINE
DCOM- 20010412
LR  - 20190921
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 112
IP  - 3
DP  - 2001 Mar
TI  - Neurophysiological mechanisms underlying motor evoked potentials in anesthetized 
      humans. Part 2. Relationship between epidurally and muscle recorded MEPs in man.
PG  - 445-52
AB  - OBJECTIVE AND METHODS: Direct (D) and transynaptic, (i.e. indirect) (I) 
      corticospinal tract (CT) discharges were simultaneously recorded epidurally with 
      muscle motor evoked potentials (MEPs) in patients under different levels of 
      anesthesia. The effects of the one, two or more equal electrical stimuli, applied 
      transcranially or directly to the motor cortex, were studied at different 
      interstimulus intervals (ISIs) to determine the optimal conditions for eliciting 
      I and MEP responses. RESULTS AND CONCLUSION: At anesthetic levels permiting large 
      D and I responses to single stimuli, optimal D and I wave facilitation and MEPs 
      occurred with two stimuli at ISIs greater than 4 ms (e.g. at 5.9 and 8 ms). When 
      single electrical stimuli elicit only a D response, optimal MEP responses are 
      determined by the number of stimuli and the recovery of CT fibers excitability 
      (e.g. at an ISI of 4 ms).
FAU - Deletis, V
AU  - Deletis V
AD  - Institute for Neurology and Neurosurgery, Beth Israel Medical Center - Singer 
      Division, 170 East End Avenue, Rm. 311, New York, NY 10128, USA. 
      vdeletis@bethisraelny.org
FAU - Rodi, Z
AU  - Rodi Z
FAU - Amassian, V E
AU  - Amassian VE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Anesthesia
MH  - Electric Stimulation
MH  - *Electrodes, Implanted
MH  - Epidural Space
MH  - Evoked Potentials, Motor/*physiology
MH  - Hand
MH  - Humans
MH  - Motor Neurons/physiology
MH  - Muscle, Skeletal/innervation/*physiology
MH  - Pyramidal Tracts/cytology/*physiology
EDAT- 2001/02/27 10:00
MHDA- 2001/04/17 10:01
CRDT- 2001/02/27 10:00
PHST- 2001/02/27 10:00 [pubmed]
PHST- 2001/04/17 10:01 [medline]
PHST- 2001/02/27 10:00 [entrez]
AID - S1388-2457(00)00557-5 [pii]
AID - 10.1016/s1388-2457(00)00557-5 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2001 Mar;112(3):445-52. doi: 10.1016/s1388-2457(00)00557-5.