PMID- 11222989
OWN - NLM
STAT- MEDLINE
DCOM- 20010621
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 893
IP  - 1-2
DP  - 2001 Mar 2
TI  - Role of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion 
      in rats.
PG  - 29-35
AB  - The CRF receptor subtype mediating the colonic and gastric motor responses to 
      central CRF was investigated in conscious rats. CRF (0.6 microg/rat) injected 
      intracerebroventicularly (i.c.v.) or 1 h water avoidance stress stimulated 
      defecation (pellet/60 min: 4.1+/-1.0 and 8.7+/-0.7 respectively vs. 0.3+/-0.3 in 
      i.c.v. vehicle/no stress). The CRF receptor 1 (CRF-R1) antagonist, NBI-27914 
      (50-100 microg/rat) injected i.c.v., abolished the colonic response to i.c.v. CRF 
      and dose-dependently reduced that induced by water avoidance stress. NBI-27914 
      (100 microg/rat) injected peripherally did not influence the defecatory response 
      to stress. The peptide CRF-R1/R2 antagonist, astressin (10 microg/rat, i.c.v.) 
      inhibited the colonic motor response to i.c.v. CRF and stress similarly as 
      NBI-27914 injected i.c.v. at 100 microg/rat. Intracisternal (i.c.) injection of 
      astressin (10 microg/rat) also completely prevented CRF (0.6 g, i.c.)-induced 
      delayed gastric emptying while i.c. NBI-27914 (50 or 100 microg) had no effect. 
      These results indicate a differential role of central CRF receptor subtypes in 
      the colonic stimulatory and gastric inhibitory motor responses to central CRF and 
      that the CRF component of stress-related activation of colonic expulsion is 
      primarily mediated by CRF-R1.
FAU - Martinez, V
AU  - Martinez V
AD  - CURE: Digestive Diseases Research Center, Veterans Administration Greater Los 
      Angeles Healthcare System, Department of Medicine, Digestive Disease Division and 
      Brain Research Institute, University of California at Los Angeles, Los Angeles, 
      CA 90073,USA.
FAU - Tache, Y
AU  - Tache Y
LA  - eng
GR  - DK-41301/DK/NIDDK NIH HHS/United States
GR  - DK33061/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Hormone Antagonists)
RN  - 0 (Peptide Fragments)
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
RN  - 170809-51-5 (astressin)
RN  - 5CLY6W2H1M (CRF receptor type 1)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Cisterna Magna/drug effects
MH  - Colon/innervation/*physiology
MH  - Corticotropin-Releasing Hormone/*administration & dosage
MH  - Defecation/drug effects
MH  - Gastric Emptying/drug effects
MH  - Gastrointestinal Motility/*drug effects/physiology
MH  - Hormone Antagonists/administration & dosage
MH  - Injections, Intraperitoneal
MH  - Injections, Intraventricular
MH  - Male
MH  - Peptide Fragments/administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors/*metabolism
MH  - Stress, Physiological
EDAT- 2001/02/27 10:00
MHDA- 2001/06/22 10:01
CRDT- 2001/02/27 10:00
PHST- 2001/02/27 10:00 [pubmed]
PHST- 2001/06/22 10:01 [medline]
PHST- 2001/02/27 10:00 [entrez]
AID - S0006-8993(00)03277-7 [pii]
AID - 10.1016/s0006-8993(00)03277-7 [doi]
PST - ppublish
SO  - Brain Res. 2001 Mar 2;893(1-2):29-35. doi: 10.1016/s0006-8993(00)03277-7.