PMID- 11223165
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20190826
IS  - 0169-328X (Print)
IS  - 0169-328X (Linking)
VI  - 87
IP  - 1
DP  - 2001 Feb 19
TI  - Localization of the human mGluR4 gene within an epilepsy susceptibility locus(1).
PG  - 109-16
AB  - The family of metabotropic glutamate receptors (mGluRs) consists of eight 
      homologous G-protein coupled receptors. Several of the mGluRs, including the 
      mGluR4 receptor subtype, are localized presynaptically; activation of this 
      receptor induces an inhibition of neurotransmitter release from nerve terminals. 
      Disruption of the mGluR4 gene in mice results in impaired motor and spatial 
      learning, and alterations in seizure susceptibility. In this study, we have 
      determined the structure of the human mGluR4 gene, as well as its chromosomal 
      localization. A comparison of the gene structure of mGluR4 with the highly 
      homologous mGluR6 receptor subtype reveals that both of the genes contain ten 
      exons with similar exon/intron boundaries. A refined localization of mGluR4 was 
      carried out by constructing a bacterial artificial chromosome clone contig of the 
      region surrounding the gene. Thirteen sequence tagged sites (STSs) were 
      identified within this contig. The gene was localized to chromosome 6 band p21.3 
      by fluorescence in situ hybridization (FISH). The mapping of the mGluR4 gene 
      indicates that it is approximately 1 megabases centromeric of the major 
      histocompatibility complex and 5 megabase from the GABA(B)R1 gene. The mGluR4 
      gene also falls within a susceptibility locus for juvenile myoclonic epilepsy 
      suggesting a potential link to this form of epilepsy.
FAU - Wong, C G
AU  - Wong CG
AD  - Department of Pharmacology, University of Toronto, Ontario, Toronto, Canada
FAU - Scherer, S W
AU  - Scherer SW
FAU - Snead, O C 3rd
AU  - Snead OC 3rd
FAU - Hampson, D R
AU  - Hampson DR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Mol Brain Res
JT  - Brain research. Molecular brain research
JID - 8908640
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - YZN9W7P1BX (metabotropic glutamate receptor 4)
SB  - IM
MH  - *Chromosome Mapping
MH  - *Chromosomes, Human, Pair 6
MH  - Exons
MH  - Gene Library
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Introns
MH  - Male
MH  - Myoclonic Epilepsy, Juvenile/*genetics
MH  - Receptors, Metabotropic Glutamate/*genetics
EDAT- 2001/02/27 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/02/27 10:00
PHST- 2001/02/27 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/02/27 10:00 [entrez]
AID - S0169328X00002837 [pii]
AID - 10.1016/s0169-328x(00)00283-7 [doi]
PST - ppublish
SO  - Brain Res Mol Brain Res. 2001 Feb 19;87(1):109-16. doi: 
      10.1016/s0169-328x(00)00283-7.