PMID- 11224147
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1473-5849 (Electronic)
IS  - 0955-8810 (Linking)
VI  - 3
IP  - 5
DP  - 1992 Oct
TI  - Discriminative stimulus effects of the optical isomers of 
      3,4-methylenedioxyamphetamine (MDA).
PG  - 443-454
AB  - The isomers of 3,4-methylenedioxyamphetamine (MDA) functioned as discriminative 
      stimuli in rats trained to discriminate either (-) MDA (1.25mg/kg) or (+) MDA 
      (1.25mg/kg) from saline. Dose- and time-response curves indicated that drug lever 
      selection occurred at doses of at least 1.00mg/kg of (-) MDA and 0.75mg/kg of (+) 
      MDA and that drug-appropriate responding for both isomers was maintained for at 
      least 90min. Cross-substitution was observed between the MDA isomers; both (+) 
      and (-) 3,4-methylenedioxymethamphetamine (MDMA) also substituted completely for 
      (+) and (-) MDA. The hallucinogens (+)-lysergic acid diethylamide (LSD) and 
      (+/-)-2,5-dimethoxy-4-methylamphetamine (DOM), substituted for (-) MDA; neither 
      mescaline nor (+) amphetamine or cocaine had (-) MDA-like effects. LSD also 
      substituted for (+) MDA; DOM, mescaline, (+) amphetamine and cocaine failed to 
      have (+) MDA-like effects. The (-) but not the (+) MDA cue was blocked by the 
      5-HT(2) antagonist pirenpirone; the dopamine (DA) antagonists SCH-23390 and (-) 
      sulpiride had no effect on either the (-) or (+) MDA cues. When animals were 
      trained to discriminate LSD (0.16mg/kg) or (+) amphetamine (1.0mg/kg) from 
      saline, neither (-) MDA nor (+) MDA substituted completely. These results 
      indicate that: (1) the stimulus effects of the isomers of MDA and MDMA are 
      similar; (2) (-) MDA may be more hallucinogenic (or more accurately, LSD- or 
      DOM-like) than (+) MDA; (3) neither (+) nor (-) MDA has potent amphetamine-like 
      effects; and (4) the effects of (-) MDA may be more serotonergic than those of 
      (+) MDA.
FAU - Broadbent, J
AU  - Broadbent J
AD  - Behavioral Pharmacology Laboratory, Department of Psychology, University of South 
      Carolina, Columbia, SC 29208, USA.
FAU - Appel, JB
AU  - Appel JB
FAU - Michael, EK
AU  - Michael EK
FAU - Ricker, JH
AU  - Ricker JH
LA  - eng
PT  - Journal Article
PL  - England
TA  - Behav Pharmacol
JT  - Behavioural pharmacology
JID - 9013016
EDAT- 1992/10/01 00:00
MHDA- 2001/02/27 10:00
CRDT- 1992/10/01 00:00
PHST- 1992/10/01 00:00 [pubmed]
PHST- 2001/02/27 10:00 [medline]
PHST- 1992/10/01 00:00 [entrez]
PST - ppublish
SO  - Behav Pharmacol. 1992 Oct;3(5):443-454.