PMID- 11231500
OWN - NLM
STAT- MEDLINE
DCOM- 20010405
LR  - 20210527
IS  - 0003-9985 (Print)
IS  - 0003-9985 (Linking)
VI  - 125
IP  - 3
DP  - 2001 Mar
TI  - A unique, complex variant philadelphia chromosome translocation in a patient with 
      typical chronic myelogenous leukemia.
PG  - 437-9
AB  - The Philadelphia (Ph) chromosome [der(22) t(9;22)(q34;q11)] is the characteristic 
      chromosomal abnormality found in chronic myelogenous leukemia (CML). This 
      chromosome has been reported in patients with other chromosomal abnormalities. In 
      this study, we describe a patient with hematologically typical chronic-phase CML 
      with an unusual and complex translocation involving chromosomes 9, 11, and 22. 
      These complex translocations were identified by G-banded conventional 
      cytogenetics and confirmed by fluorescence in situ hybridization (FISH) using 
      whole chromosome painting probes (wcp). To the best of our knowledge, these are 
      unique translocations involving the short and the long arms of chromosome 9 in 4 
      different translocations with the short arm of chromosome 11 and the long arm of 
      chromosome 22.
FAU - Oudat, R
AU  - Oudat R
AD  - Department of Cytogenetics, The University of Texas, MD Anderson Cancer Center, 
      Houston 77030, USA.
FAU - Khan, Z
AU  - Khan Z
FAU - Glassman, A B
AU  - Glassman AB
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Pathol Lab Med
JT  - Archives of pathology & laboratory medicine
JID - 7607091
RN  - 0 (Antineoplastic Agents)
RN  - X6Q56QN5QC (Hydroxyurea)
SB  - IM
MH  - Adult
MH  - Antineoplastic Agents/therapeutic use
MH  - Chromosome Painting
MH  - Humans
MH  - Hydroxyurea/therapeutic use
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy/*genetics/pathology
MH  - Male
MH  - *Philadelphia Chromosome
MH  - *Translocation, Genetic
EDAT- 2001/03/07 10:00
MHDA- 2001/04/06 10:01
CRDT- 2001/03/07 10:00
PHST- 2001/03/07 10:00 [pubmed]
PHST- 2001/04/06 10:01 [medline]
PHST- 2001/03/07 10:00 [entrez]
AID - 10.5858/2001-125-0437-AUCVPC [doi]
PST - ppublish
SO  - Arch Pathol Lab Med. 2001 Mar;125(3):437-9. doi: 10.5858/2001-125-0437-AUCVPC.