PMID- 11231630
OWN - NLM
STAT- MEDLINE
DCOM- 20010405
LR  - 20141120
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 7
IP  - 3
DP  - 2001 Mar
TI  - ORP150 protects against hypoxia/ischemia-induced neuronal death.
PG  - 317-23
AB  - Oxygen-regulated protein 150 kD (ORP150) is a novel 
      endoplasmic-reticulum-associated chaperone induced by hypoxia/ischemia. Although 
      ORP150 was sparingly upregulated in neurons from human brain undergoing ischemic 
      stress, there was robust induction in astrocytes. Cultured neurons overexpressing 
      ORP150 were resistant to hypoxemic stress, whereas astrocytes with inhibited 
      ORP150 expression were more vulnerable. Mice with targeted neuronal 
      overexpression of ORP150 had smaller strokes compared with controls. Neurons with 
      increased ORP150 demonstrated suppressed caspase-3-like activity and enhanced 
      brain-derived neurotrophic factor (BDNF) under hypoxia signaling. These data 
      indicate that ORP150 is an integral participant in ischemic cytoprotective 
      pathways.
FAU - Tamatani, M
AU  - Tamatani M
AD  - Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka 
      University, Osaka, Japan. tamatani@h8.dion.ne.jp
FAU - Matsuyama, T
AU  - Matsuyama T
FAU - Yamaguchi, A
AU  - Yamaguchi A
FAU - Mitsuda, N
AU  - Mitsuda N
FAU - Tsukamoto, Y
AU  - Tsukamoto Y
FAU - Taniguchi, M
AU  - Taniguchi M
FAU - Che, Y H
AU  - Che YH
FAU - Ozawa, K
AU  - Ozawa K
FAU - Hori, O
AU  - Hori O
FAU - Nishimura, H
AU  - Nishimura H
FAU - Yamashita, A
AU  - Yamashita A
FAU - Okabe, M
AU  - Okabe M
FAU - Yanagi, H
AU  - Yanagi H
FAU - Stern, D M
AU  - Stern DM
FAU - Ogawa, S
AU  - Ogawa S
FAU - Tohyama, M
AU  - Tohyama M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (HSP70 Heat-Shock Proteins)
RN  - 0 (Proteins)
RN  - 0 (oxygen-regulated proteins)
SB  - IM
MH  - Animals
MH  - Brain/cytology/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cell Death/*physiology
MH  - *Cell Hypoxia
MH  - HSP70 Heat-Shock Proteins
MH  - Humans
MH  - Mice
MH  - Neurons/metabolism/*pathology
MH  - Proteins/antagonists & inhibitors/*physiology
EDAT- 2001/03/07 10:00
MHDA- 2001/04/06 10:01
CRDT- 2001/03/07 10:00
PHST- 2001/03/07 10:00 [pubmed]
PHST- 2001/04/06 10:01 [medline]
PHST- 2001/03/07 10:00 [entrez]
AID - 85463 [pii]
AID - 10.1038/85463 [doi]
PST - ppublish
SO  - Nat Med. 2001 Mar;7(3):317-23. doi: 10.1038/85463.