PMID- 11231910
OWN - NLM
STAT- MEDLINE
DCOM- 20010517
LR  - 20190831
IS  - 1524-4636 (Electronic)
IS  - 1079-5642 (Linking)
VI  - 21
IP  - 3
DP  - 2001 Mar
TI  - Elevated circulating levels of monocyte chemoattractant protein-1 in patients 
      with restenosis after coronary angioplasty.
PG  - 327-34
AB  - Inflammation plays a pathogenic role in the development of restenosis after 
      percutaneous transluminal coronary angioplasty (PTCA). Monocyte chemoattractant 
      protein-1 (MCP-1) is a potent chemoattractant of monocytes; however, its role in 
      the pathophysiology of restenosis is still unclear. We set out to investigate the 
      role of MCP-1 in restenosis after PTCA. In addition, we tested the hypothesis 
      that MCP-1 exerts its effect, at least in part, by inducing O(2)(-) generation in 
      circulating monocytes. Plasma levels of MCP-1 were measured before and 1, 5, 15, 
      and 180 days after PTCA in 50 patients (30 males and 20 females, aged 62+/-5 
      years) who underwent PTCA and who had repeated angiograms at 6-month follow-up. 
      Restenosis occurred in 14 (28%) patients. The MCP-1 level was no different at 
      baseline between patients with or without restenosis. However, after the 
      procedure, restenotic patients, compared with nonrestenotic patients, had 
      statistically significant (P<0.0001) elevated levels of MCP-1. In contrast, 
      plasma levels of other chemokines, such as RANTES and interleukin-8, did not 
      differ between the 2 groups after PTCA. Higher MCP-1 throughout the study was 
      correlated with restenosis. Moreover, increased MCP-1 was significantly 
      correlated with increased monocyte activity, as reflected by enhanced O(2)(-) 
      generation. Finally, multivariate regression analysis showed that the MCP-1 
      plasma level measured 15 days after PTCA was the only statistically significant 
      independent predictor of restenosis (beta=0.688, P<0.0001). This study suggests 
      that MCP-1 production and macrophage accumulation in the balloon-injured vessel 
      may play a pivotal role in restenosis after PTCA. MCP-1 may induce luminal 
      renarrowing, at least in part, by inducing O(2)(-) release in monocytes. Further 
      understanding of the mechanism(s) by which MCP-1 is produced and acts after 
      arterial injury may provide insight into therapies to limit the progression of 
      atherosclerosis and restenosis after balloon angioplasty.
FAU - Cipollone, F
AU  - Cipollone F
AD  - Department of Medicine and Aging, University of Chieti "G D'Annunzio" School of 
      Medicine, Chieti, Italy.
FAU - Marini, M
AU  - Marini M
FAU - Fazia, M
AU  - Fazia M
FAU - Pini, B
AU  - Pini B
FAU - Iezzi, A
AU  - Iezzi A
FAU - Reale, M
AU  - Reale M
FAU - Paloscia, L
AU  - Paloscia L
FAU - Materazzo, G
AU  - Materazzo G
FAU - D'Annunzio, E
AU  - D'Annunzio E
FAU - Conti, P
AU  - Conti P
FAU - Chiarelli, F
AU  - Chiarelli F
FAU - Cuccurullo, F
AU  - Cuccurullo F
FAU - Mezzetti, A
AU  - Mezzetti A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Arterioscler Thromb Vasc Biol
JT  - Arteriosclerosis, thrombosis, and vascular biology
JID - 9505803
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Interleukin-8)
RN  - 0 (Reactive Oxygen Species)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
CIN - Arterioscler Thromb Vasc Biol. 2001 Mar;21(3):297-9. PMID: 11231906
CIN - Arterioscler Thromb Vasc Biol. 2001 Jun;21(6):1090-1. PMID: 11397725
MH  - Aged
MH  - Analysis of Variance
MH  - *Angioplasty, Balloon, Coronary
MH  - Chemokine CCL2/*blood
MH  - Chemokine CCL5/blood
MH  - Coronary Disease/*blood/therapy
MH  - Female
MH  - Humans
MH  - Interleukin-8/blood
MH  - Male
MH  - Middle Aged
MH  - Monocytes/cytology/drug effects/metabolism
MH  - Reactive Oxygen Species/metabolism
MH  - Recurrence
MH  - Tetradecanoylphorbol Acetate/pharmacology
MH  - Time Factors
EDAT- 2001/03/07 10:00
MHDA- 2001/05/22 10:01
CRDT- 2001/03/07 10:00
PHST- 2001/03/07 10:00 [pubmed]
PHST- 2001/05/22 10:01 [medline]
PHST- 2001/03/07 10:00 [entrez]
AID - 10.1161/01.atv.21.3.327 [doi]
PST - ppublish
SO  - Arterioscler Thromb Vasc Biol. 2001 Mar;21(3):327-34. doi: 
      10.1161/01.atv.21.3.327.