PMID- 11233293
OWN - NLM
STAT- MEDLINE
DCOM- 20010510
LR  - 20191210
IS  - 0015-5691 (Print)
IS  - 0015-5691 (Linking)
VI  - 117
IP  - 1
DP  - 2001 Jan
TI  - [Recent advances in research on nicotine dependence and reward mechanism].
PG  - 27-34
AB  - Tobacco/nicotine dependence involves both psychological and physiologic 
      dependence on nicotine. A recent summary of the clinical aspects of nicotine 
      dependence disorders is provided in the ICD-10 of the WHO. There is growing 
      evidence suggesting that nicotine depends on dopamine (DA) for its reinforcing 
      effects. Suppression of DA function using DA-receptor antagonist affects the 
      intravenous self-administration of nicotine, the discriminative properties of 
      nicotine, nicotine-induced intracranial self-stimulation and nicotine-conditioned 
      place preference. The increase inextracellular DA in the nucleus accumbens (NAcc) 
      is a major factor that mediates the self-administration of nicotine. Recently, 
      alpha 7-nicotinic receptors in the ventral tegmental area (VTA) contribute to the 
      acute effects of nicotine on the mesolymbic DA system, reinforcing effects of 
      nicotine and withdrawal symptoms from nicotine. The action of glutamate (Glu) at 
      N-methyl-D-aspartate (NMDA)-sensitive receptors within the VTA is required for 
      nicotine to stimulate DA release in the NAcc. Molecular epidemiological studies 
      have shown that smoking behavior is more strongly influenced by a combination of 
      the serotonin transporter gene and the neuroticism than by either factor alone. 
      Clinically, bupropion, an antidepressant, has been licensed for use in USA to 
      help patients stop smoking. The underlying mechanism is thought to be mediated by 
      increasing the concentration of DA in the NAcc.
FAU - Miyasato, K
AU  - Miyasato K
AD  - Department of Psychiatry, Saint Marianna University School of Medicine, 2-16-1, 
      Sugao, Miyamae-ku, Kawasaki 216-8511, Japan. miyasato@marianna-u.ac.jp
LA  - jpn
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Yakurigaku Zasshi
JT  - Nihon yakurigaku zasshi. Folia pharmacologica Japonica
JID - 0420550
RN  - 0 (Antidepressive Agents)
RN  - 0 (Receptors, Nicotinic)
RN  - 01ZG3TPX31 (Bupropion)
RN  - 0RH81L854J (Glutamine)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/therapeutic use
MH  - Brain/metabolism
MH  - Bupropion/therapeutic use
MH  - Dopamine/physiology
MH  - Glutamine/physiology
MH  - Humans
MH  - N-Methylaspartate/physiology
MH  - Receptors, Nicotinic/physiology
MH  - *Reinforcement, Psychology
MH  - *Tobacco Use Disorder/drug therapy/etiology
RF  - 41
EDAT- 2001/03/10 10:00
MHDA- 2001/05/22 10:01
CRDT- 2001/03/10 10:00
PHST- 2001/03/10 10:00 [pubmed]
PHST- 2001/05/22 10:01 [medline]
PHST- 2001/03/10 10:00 [entrez]
AID - 10.1254/fpj.117.27 [doi]
PST - ppublish
SO  - Nihon Yakurigaku Zasshi. 2001 Jan;117(1):27-34. doi: 10.1254/fpj.117.27.