PMID- 11234744
OWN - NLM
STAT- MEDLINE
DCOM- 20010607
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 12
IP  - 3
DP  - 2001 Mar 5
TI  - Induction of c-fos in hamster accessory olfactory bulbs by natural and cloned 
      aphrodisin.
PG  - 449-52
AB  - Male hamsters were exposed to the female pheromone, aphrodisin (APH), its cloned 
      protein backbone (rAPH), and the homologous lipocalin, beta-lactoglobulin 
      (beta-LG). Of these, only APH elicited mating behavior. Enhanced c-fos protein 
      was found in the nuclei of neurons in the accessory olfactory bulb (AOB) after 
      exposure to these stimuli. Relative to beta-LG, both rAPH and APH produced 
      significant increases in AOB labeling. The modest labeling elicited by rAPH was 
      evenly distributed, but the heavier staining elicited by APH was concentrated in 
      the caudal region of the AOB. Thus, pheromone receptor neurons in the basal 
      compartment of the vomeronasal epithelium, which project to the caudal region of 
      the AOB, may respond to APH and provide the input which drives mating behavior.
FAU - Jang, T
AU  - Jang T
AD  - Worcester Foundation for Biomedical Research Shrewsbury, MA 01545, USA.
FAU - Singer, A G
AU  - Singer AG
FAU - O'Connell, R J
AU  - O'Connell RJ
LA  - eng
GR  - DC00131/DC/NIDCD NIH HHS/United States
GR  - DC00241/DC/NIDCD NIH HHS/United States
GR  - HD19764/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Pheromones)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Sex Attractants)
RN  - 0 (aphrodisin protein, Mesocricetus auratus)
SB  - IM
MH  - Animals
MH  - Cloning, Molecular
MH  - Cricetinae
MH  - Immunohistochemistry
MH  - Male
MH  - Mesocricetus
MH  - Olfactory Bulb/chemistry/cytology/*metabolism
MH  - Olfactory Receptor Neurons/chemistry/metabolism
MH  - Pheromones
MH  - Proteins/genetics/*pharmacology
MH  - Proto-Oncogene Proteins c-fos/analysis/*biosynthesis
MH  - Recombinant Proteins/pharmacology
MH  - Sex Attractants/genetics/*pharmacology
MH  - Sexual Behavior, Animal/physiology
MH  - Smell/physiology
MH  - Vomeronasal Organ/cytology/metabolism
EDAT- 2001/03/10 10:00
MHDA- 2001/06/08 10:01
CRDT- 2001/03/10 10:00
PHST- 2001/03/10 10:00 [pubmed]
PHST- 2001/06/08 10:01 [medline]
PHST- 2001/03/10 10:00 [entrez]
AID - 10.1097/00001756-200103050-00006 [doi]
PST - ppublish
SO  - Neuroreport. 2001 Mar 5;12(3):449-52. doi: 10.1097/00001756-200103050-00006.