PMID- 11236824
OWN - NLM
STAT- MEDLINE
DCOM- 20010510
LR  - 20191104
IS  - 0893-0341 (Print)
IS  - 0893-0341 (Linking)
VI  - 15
IP  - 1
DP  - 2001 Jan-Mar
TI  - Activation mechanism of brain microglia in patients with diffuse neurofibrillary 
      tangles with calcification: a comparison with Alzheimer disease.
PG  - 45-50
AB  - Diffuse neurofibrillary tangles with calcification (DNTC) is an atypical dementia 
      and is characterized pathologically by diffuse neurofibrillary tangles (NFTs) 
      without senile plaques (SPs). In this study, we investigated the distribution of 
      human leukocyte antigen (HLA)-DR-positive activated microglia in postmortem brain 
      tissue of six patients with DNTC and six patients with Alzheimer disease (AD). 
      HLA-DR-positive activated microglia were observed to associate with SPs in AD. In 
      the DNTC brain, which lacks SPs, HLA-DR-positive microglia were mainly 
      accumulated around weakly tau-positive NFTs, which were also positive for 
      anti-amyloid-P and anti-C3d antibodies. The results of this study suggest that 
      the complement pathway is also activated in the DNTC brain and that immune and 
      inflammatory responses, including microglia activation, may occur around 
      extracellular NFTs in DNTC patients.
FAU - Imamura, K
AU  - Imamura K
AD  - Department of Neurology, Okazaki City Hospital, Aichi, Japan.
FAU - Sawada, M
AU  - Sawada M
FAU - Ozaki, N
AU  - Ozaki N
FAU - Naito, H
AU  - Naito H
FAU - Iwata, N
AU  - Iwata N
FAU - Ishihara, R
AU  - Ishihara R
FAU - Takeuchi, T
AU  - Takeuchi T
FAU - Shibayama, H
AU  - Shibayama H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Alzheimer Dis Assoc Disord
JT  - Alzheimer disease and associated disorders
JID - 8704771
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Aged
MH  - Autopsy
MH  - Brain Diseases/*physiopathology
MH  - Calcinosis
MH  - Dementia/*physiopathology
MH  - Female
MH  - HLA-DR Antigens/*analysis
MH  - Humans
MH  - Inflammation
MH  - Male
MH  - Microglia/immunology/*pathology
MH  - Middle Aged
MH  - Neurofibrillary Tangles/*pathology
MH  - Plaque, Amyloid/immunology/*pathology
EDAT- 2001/03/10 10:00
MHDA- 2001/05/22 10:01
CRDT- 2001/03/10 10:00
PHST- 2001/03/10 10:00 [pubmed]
PHST- 2001/05/22 10:01 [medline]
PHST- 2001/03/10 10:00 [entrez]
AID - 10.1097/00002093-200101000-00006 [doi]
PST - ppublish
SO  - Alzheimer Dis Assoc Disord. 2001 Jan-Mar;15(1):45-50. doi: 
      10.1097/00002093-200101000-00006.