PMID- 11239484
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20220409
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1504
IP  - 1
DP  - 2001 Mar 1
TI  - Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome 
      c oxidase.
PG  - 46-57
AB  - Nitric oxide (NO) and its derivatives inhibit mitochondrial respiration by a 
      variety of means. Nanomolar concentrations of NO immediately, specifically and 
      reversibly inhibit cytochrome oxidase in competition with oxygen, in isolated 
      cytochrome oxidase, mitochondria, nerve terminals, cultured cells and tissues. 
      Higher concentrations of NO and its derivatives (peroxynitrite, nitrogen dioxide 
      or nitrosothiols) can cause irreversible inhibition of the respiratory chain, 
      uncoupling, permeability transition, and/or cell death. Isolated mitochondria, 
      cultured cells, isolated tissues and animals in vivo display respiratory 
      inhibition by endogenously produced NO from constitutive isoforms of NO synthase 
      (NOS), which may be largely mediated by NO inhibition of cytochrome oxidase. 
      Cultured cells expressing the inducible isoform of NOS (iNOS) can acutely and 
      reversibly inhibit their own cellular respiration and that of co-incubated cells 
      due to NO inhibition of cytochrome oxidase, but after longer-term incubation 
      result in irreversible inhibition of cellular respiration due to NO or its 
      derivatives. Thus the NO inhibition of cytochrome oxidase may be involved in the 
      physiological and/or pathological regulation of respiration rate, and its 
      affinity for oxygen.
FAU - Brown, G C
AU  - Brown GC
AD  - Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge 
      CB2 1QW, UK. gcb@mole.bio.cam.ac.uk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Enzyme Inhibitors)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - EC 1.14.13.39 (NOS1 protein, human)
RN  - EC 1.14.13.39 (NOS2 protein, human)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type I)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type II)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - Electron Transport Complex IV/*antagonists & inhibitors
MH  - Enzyme Inhibitors/pharmacology
MH  - Humans
MH  - Mitochondria/enzymology/*metabolism
MH  - Nitric Oxide/*metabolism/pharmacology
MH  - Nitric Oxide Synthase/antagonists & inhibitors/metabolism
MH  - Nitric Oxide Synthase Type I
MH  - Nitric Oxide Synthase Type II
MH  - Oxygen Consumption/drug effects
RF  - 97
EDAT- 2001/03/10 10:00
MHDA- 2001/05/01 10:01
CRDT- 2001/03/10 10:00
PHST- 2001/03/10 10:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/03/10 10:00 [entrez]
AID - S0005-2728(00)00238-3 [pii]
AID - 10.1016/s0005-2728(00)00238-3 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2001 Mar 1;1504(1):46-57. doi: 
      10.1016/s0005-2728(00)00238-3.