PMID- 11239980
OWN - NLM
STAT- MEDLINE
DCOM- 20010510
LR  - 20190712
IS  - 0031-9384 (Print)
IS  - 0031-9384 (Linking)
VI  - 72
IP  - 1-2
DP  - 2001 Jan
TI  - Alarm pheromone enhances stress-induced hyperthermia in rats.
PG  - 45-50
AB  - Behavioral and physiological effects of alarm pheromones emanating from stressed 
      conspecific animals were investigated. Experimentally naive male Wistar rats were 
      exposed to the test chambers containing alarm pheromones, which had been released 
      by other rats receiving foot shocks in the same chamber beforehand. Along with 
      behavioral analysis, the heart rate (HR) and core body temperature (cBT) were 
      measured simultaneously using a biotelemetory system. Exposure to the alarm 
      pheromones increased freezing, sniffing and walking and decreased resting as 
      compared with rats exposed to control odors. In addition, these pheromone-exposed 
      animals showed consistent increases in body temperature, i.e., stress-induced 
      hyperthermia. After exposure to the alarm substances, immunoreactivity to nuclear 
      Fos protein in the mitral cell layer in the accessory olfactory bulb (AOB) also 
      increased compared with the reaction to control odors. These results suggest that 
      an alarm pheromone enhances stress responses of conspecific animals both 
      behaviorally and physiologically, and that these effects are mediated via 
      activation of the AOB.
FAU - Kikusui, T
AU  - Kikusui T
AD  - Laboratory of Veterinary Ethology, The University of Tokyo, 1-1-1 Yayoi, 
      Bunkyo-ku, Tokyo 113-8657, Japan. akikus@mail.ecc.u-tokyo.ac.jp
FAU - Takigami, S
AU  - Takigami S
FAU - Takeuchi, Y
AU  - Takeuchi Y
FAU - Mori, Y
AU  - Mori Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Pheromones)
RN  - 0 (Proto-Oncogene Proteins c-fos)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects/physiology
MH  - Body Temperature/drug effects/physiology
MH  - Fever/*physiopathology
MH  - Heart Rate/drug effects/physiology
MH  - Immunohistochemistry
MH  - Male
MH  - Olfactory Bulb/drug effects/metabolism
MH  - Pheromones/*pharmacology
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/*physiopathology
EDAT- 2001/03/10 10:00
MHDA- 2001/05/22 10:01
CRDT- 2001/03/10 10:00
PHST- 2001/03/10 10:00 [pubmed]
PHST- 2001/05/22 10:01 [medline]
PHST- 2001/03/10 10:00 [entrez]
AID - S0031-9384(00)00370-X [pii]
AID - 10.1016/s0031-9384(00)00370-x [doi]
PST - ppublish
SO  - Physiol Behav. 2001 Jan;72(1-2):45-50. doi: 10.1016/s0031-9384(00)00370-x.