PMID- 11240586
OWN - NLM
STAT- MEDLINE
DCOM- 20010329
LR  - 20190813
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 42
IP  - 2
DP  - 2001 Feb
TI  - An animal model of nonconvulsive status epilepticus: a contribution to clinical 
      controversies.
PG  - 171-80
AB  - PURPOSE: To characterize electroencephalographic and behavioral effects as well 
      as electrophysiologic and morphologic consequences of a subconvulsive dose of 
      pilocarpine in lithium chloride-pretreated rats. METHODS: Pilocarpine (15 mg/kg) 
      was administered intraperitoneally to adult rats pretreated with lithium chloride 
      (3 mEq/kg, i.p.). Behavior was observed for 2 h and videotaped in three 
      consecutive sessions. At the same time, EEG was recorded from the sensorimotor 
      cortex and the dorsal hippocampus. Threshold intensities of currents necessary to 
      elicit hippocampal afterdischarges were determined 24 h and 1 week after the 
      pilocarpine administration. The brains were histologically examined 1 week after 
      pilocarpine administration using Nissl stain. RESULTS: Pilocarpine induced 
      time-limited nonconvulsive status epilepticus (NCSE). Epileptic EEG activity 
      concurrent with prominent behavioral features was observed both in the neocortex 
      and, predominantly, in the hippocampus. No changes in afterdischarge thresholds 
      were observed in the dorsal hippocampus 24 h and 1 week after NCSE. One week 
      after NCSE, seizure-related brain damage was found mainly in the motor 
      neocortical fields. CONCLUSIONS: Pilocarpine-induced NCSE in rats strongly 
      resembles a short-term human complex partial status epilepticus. Our animal model 
      is suitable for studying the possible adverse effects of prolonged nonconvulsive 
      seizures.
FAU - Krsek, P
AU  - Krsek P
AD  - Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 
      1083, CZ-142 20 Prague 4, Czech Republic.
FAU - Mikulecka, A
AU  - Mikulecka A
FAU - Druga, R
AU  - Druga R
FAU - Hlinak, Z
AU  - Hlinak Z
FAU - Kubova, H
AU  - Kubova H
FAU - Mares, P
AU  - Mares P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 01MI4Q9DI3 (Pilocarpine)
RN  - G4962QA067 (Lithium Chloride)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects/physiology
MH  - *Disease Models, Animal
MH  - Electroencephalography/*drug effects/statistics & numerical data
MH  - Hippocampus/drug effects/physiopathology
MH  - Humans
MH  - Lithium Chloride/pharmacology
MH  - Male
MH  - Motor Activity/drug effects/physiology
MH  - Neocortex/drug effects/physiopathology
MH  - Pilocarpine/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Status Epilepticus/*chemically induced/diagnosis/*physiopathology
MH  - Videotape Recording
EDAT- 2001/03/10 10:00
MHDA- 2001/04/03 10:01
CRDT- 2001/03/10 10:00
PHST- 2001/03/10 10:00 [pubmed]
PHST- 2001/04/03 10:01 [medline]
PHST- 2001/03/10 10:00 [entrez]
AID - epi35799 [pii]
AID - 10.1046/j.1528-1157.2001.35799.x [doi]
PST - ppublish
SO  - Epilepsia. 2001 Feb;42(2):171-80. doi: 10.1046/j.1528-1157.2001.35799.x.