PMID- 11240591
OWN - NLM
STAT- MEDLINE
DCOM- 20010329
LR  - 20211203
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 42
IP  - 2
DP  - 2001 Feb
TI  - Contribution of the MHC class II antigens to the etiology of infantile spasm in 
      Mexican Mestizos.
PG  - 210-5
AB  - PURPOSE: Infantile spasms (ISs) are age-dependant epileptic seizures, which may 
      be flexor, extensor, lightning or nods, or mixed. The aim of this study was the 
      analysis of genetic factors within the human leukocyte antigen (HLA) complex 
      associated with ISs. METHODS: Sixty-five patients diagnosed according to the 
      established international criteria were compared with 229 healthy individuals; 
      all of them were Mexican Mestizos. Five families were also analyzed (seven 
      affected and five healthy sibs); HLA class I and class II antigens were typed 
      using the standard microlymphocytotoxicity methods. RESULTS: The findings showed 
      female gender preference (2:1). Two thirds were symptomatic, and prevalent 
      seizures were of mixed type (67%). A strong association with HLA-DR17 was 
      detected in the IS group (pc < 0.01; OR = 3.6; EF = 0.20). DR17 was also found 
      increased in the symptomatic patients (p = 0.009; OR = 3.16) and in those with 
      other types of seizures (p = 0.001; OR = 2.0). Conversely, HLA-DQ6 was 
      significantly decreased (pc < 0.002; PF = 0.37) in the total and in the 
      symptomatic groups (p < 0.01). Haplotype linkage was not confirmed in the 
      families; however, those with more than one affected sib shared at least one 
      haplotype. CONCLUSIONS: These findings suggest the contribution of DR locus to 
      the susceptibility and the participation of DQ region in the resistance to IS. 
      Severity seems also to be influenced by HLA-DR17, and therefore class II typing 
      may be a helpful tool for disease prognosis.
FAU - Suastegui, R A
AU  - Suastegui RA
AD  - Department of Immunogenetics, Instituto de Diagnostico y Referencia 
      Epidemiologicos (InDRE), SSA, Mexico City, Mexico.
FAU - De La Rosa, G
AU  - De La Rosa G
FAU - Carranza, J M
AU  - Carranza JM
FAU - Gonzalez-Astiazaran, A
AU  - Gonzalez-Astiazaran A
FAU - Gorodezky, C
AU  - Gorodezky C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ6 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DRw17 antigen)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Comorbidity
MH  - Ethnicity/*genetics
MH  - Family
MH  - Female
MH  - Genes, MHC Class I/genetics
MH  - Genes, MHC Class II/*genetics
MH  - Genetic Linkage
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DR Antigens/genetics
MH  - HLA-DR Serological Subtypes
MH  - Haplotypes
MH  - Humans
MH  - Infant
MH  - Male
MH  - Mexico/epidemiology
MH  - Pedigree
MH  - Prognosis
MH  - Rural Population
MH  - Sex Factors
MH  - Spasms, Infantile/diagnosis/epidemiology/*genetics
EDAT- 2001/03/10 10:00
MHDA- 2001/04/03 10:01
CRDT- 2001/03/10 10:00
PHST- 2001/03/10 10:00 [pubmed]
PHST- 2001/04/03 10:01 [medline]
PHST- 2001/03/10 10:00 [entrez]
AID - epi22700 [pii]
AID - 10.1046/j.1528-1157.2001.22700.x [doi]
PST - ppublish
SO  - Epilepsia. 2001 Feb;42(2):210-5. doi: 10.1046/j.1528-1157.2001.22700.x.