PMID- 11241329
OWN - NLM
STAT- MEDLINE
DCOM- 20010412
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 96
IP  - 1
DP  - 2001 Feb 20
TI  - Involvement of the hepatocyte growth factor/scatter factor receptor c-met and of 
      Bcl-xL in the resistance of oropharyngeal cancer to ionizing radiation.
PG  - 41-54
AB  - The activation of cytoplasmic signal transduction pathways by a number of growth 
      factors and their tyrosine-kinase receptors, including hepatocyte growth 
      factor/scatter factor (HGF/SF) and its receptor c-met, exerts an inhibitory 
      influence on apoptosis induced by ionizing radiation in vitro. The clinical 
      relevance of the aforementioned ligand-receptor pair, of Bcl-xL, which is 
      targeted by HGF/SF/c-met signaling, and of Bcl-2, was assessed by evaluating 
      their predictive and prognostic impact in a cohort of 97 patients with radically 
      irradiated squamous cell cancers of the oropharynx. Immunohistochemical 
      expression of c-met and Bcl-xL was correlated with decreased rates of complete 
      remission of the primary tumor in both the univariate (c-met: P = 0.01; Bcl-xL: P 
      = 0.001) and multivariate analyses. Expression of c-met was, moreover, a 
      significant and independent predictor of impaired local failure-free survival (P 
      = 0.003), disease-free survival (P = 0.003) and overall survival (p = 0.001). 
      Bcl-2 expression was, on the other hand, associated with a favorable outcome, in 
      terms of both local failure-free survival (P = 0.01) and overall survival (P = 
      0.001). In accordance with in vitro data, c-met and Bcl-xL appear to be involved 
      in the resistance of oropharyngeal cancers to ionizing radiation, and may 
      therefore represent attractive targets for radiosensitization.
FAU - Aebersold, D M
AU  - Aebersold DM
AD  - Department of Radiation Oncology, Inselspital, University of Bern, Bern, 
      Switzerland.
FAU - Kollar, A
AU  - Kollar A
FAU - Beer, K T
AU  - Beer KT
FAU - Laissue, J
AU  - Laissue J
FAU - Greiner, R H
AU  - Greiner RH
FAU - Djonov, V
AU  - Djonov V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (BCL2L1 protein, human)
RN  - 0 (Ligands)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (bcl-X Protein)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Aged
MH  - Apoptosis/radiation effects
MH  - Biopsy
MH  - Carcinoma, Squamous Cell/metabolism/mortality/*radiotherapy
MH  - Cohort Studies
MH  - Cytoplasm/metabolism
MH  - Disease-Free Survival
MH  - Female
MH  - Hepatocyte Growth Factor/biosynthesis/*physiology
MH  - Humans
MH  - Immunohistochemistry
MH  - Ligands
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Oropharyngeal Neoplasms/metabolism/mortality/*radiotherapy
MH  - Proto-Oncogene Proteins c-bcl-2/biosynthesis/*physiology
MH  - Proto-Oncogene Proteins c-met/biosynthesis/*physiology
MH  - *Radiation Tolerance
MH  - Radiation, Ionizing
MH  - Remission Induction
MH  - Signal Transduction
MH  - Time Factors
MH  - Treatment Outcome
MH  - bcl-X Protein
EDAT- 2001/03/10 10:00
MHDA- 2001/04/17 10:01
CRDT- 2001/03/10 10:00
PHST- 2001/03/10 10:00 [pubmed]
PHST- 2001/04/17 10:01 [medline]
PHST- 2001/03/10 10:00 [entrez]
AID - 10.1002/1097-0215(20010220)96:1<41::AID-IJC5>3.0.CO;2-F [pii]
AID - 10.1002/1097-0215(20010220)96:1<41::aid-ijc5>3.0.co;2-f [doi]
PST - ppublish
SO  - Int J Cancer. 2001 Feb 20;96(1):41-54. doi: 
      10.1002/1097-0215(20010220)96:1<41::aid-ijc5>3.0.co;2-f.