PMID- 11243468
OWN - NLM
STAT- MEDLINE
DCOM- 20010524
LR  - 20181113
IS  - 1044-9523 (Print)
IS  - 1044-9523 (Linking)
VI  - 12
IP  - 2
DP  - 2001 Feb
TI  - DNA recognition by the aberrant retinoic acid receptors implicated in human acute 
      promyelocytic leukemia.
PG  - 85-98
AB  - Human acute promyelocytic leukemias (APLs) are associated with chromosomal 
      translocations that replace the NH2 terminus of wild-type retinoic acid receptor 
      (RAR) alpha with portions of the promyelocytic leukemia protein (PML) or 
      promyelocytic leukemia zinc-finger protein (PLZF). The wild-type RARalpha readily 
      forms heterodimers with the retinoid X receptors (RXRs), and these RAR/RXR 
      heterodimers appear to be the principal mediators of retinoid signaling in normal 
      cells. In contrast, PML-RARalpha and PLZF-RARa display an enhanced ability to 
      form homodimers, and this enhanced homodimer formation is believed to contribute 
      to the neoplastic properties of these chimeric oncoproteins. We report here that 
      the DNA recognition specificity of the RXRalpha/RARa heterodimer, which is 
      presumed to be the dominant receptor species in normal cells, differs from that 
      of the PML-RARalpha and PLZF-RARalpha homodimers, which are thought to prevail in 
      the oncogenic cell. We suggest that differences in target gene recognition by the 
      normal and oncogenic RARalpha proteins may contribute to the leukemogenic 
      phenotype.
FAU - Hauksdottir, H
AU  - Hauksdottir H
AD  - Section of Microbiology, Division of Biological Sciences, University of 
      California at Davis, 95616, USA.
FAU - Privalsky, M L
AU  - Privalsky ML
LA  - eng
GR  - R37 CA053394/CA/NCI NIH HHS/United States
GR  - DK54064/DK/NIDDK NIH HHS/United States
GR  - CA53394/CA/NCI NIH HHS/United States
GR  - R37 CA053394-10/CA/NCI NIH HHS/United States
GR  - R01 DK053528/DK/NIDDK NIH HHS/United States
GR  - R01 DK053528-05A1S1/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell Growth Differ
JT  - Cell growth & differentiation : the molecular biology journal of the American 
      Association for Cancer Research
JID - 9100024
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Promyelocytic Leukemia Protein)
RN  - 0 (Promyelocytic Leukemia Zinc Finger Protein)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 143220-95-5 (PML protein, human)
RN  - 147855-37-6 (ZBTB16 protein, human)
SB  - IM
MH  - Amino Acid Sequence/genetics
MH  - Amino Acid Substitution
MH  - DNA-Binding Proteins/chemistry/*genetics/metabolism
MH  - Humans
MH  - Kruppel-Like Transcription Factors
MH  - Leukemia, Promyelocytic, Acute/*genetics
MH  - Neoplasm Proteins/chemistry/*genetics/metabolism
MH  - *Nuclear Proteins
MH  - Promyelocytic Leukemia Protein
MH  - Promyelocytic Leukemia Zinc Finger Protein
MH  - Protein Binding
MH  - Receptors, Retinoic Acid/*chemistry/*genetics/metabolism
MH  - Recombinant Fusion Proteins/chemistry/genetics
MH  - Retinoid X Receptors
MH  - Transcription Factors/*chemistry/*genetics/metabolism
MH  - Translocation, Genetic
MH  - Tumor Suppressor Proteins
PMC - PMC2712924
MID - NIHMS92280
EDAT- 2001/03/13 10:00
MHDA- 2001/05/26 10:01
PMCR- 2009/07/20
CRDT- 2001/03/13 10:00
PHST- 2001/03/13 10:00 [pubmed]
PHST- 2001/05/26 10:01 [medline]
PHST- 2001/03/13 10:00 [entrez]
PHST- 2009/07/20 00:00 [pmc-release]
PST - ppublish
SO  - Cell Growth Differ. 2001 Feb;12(2):85-98.