PMID- 11246458
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20190201
IS  - 0003-4800 (Print)
IS  - 0003-4800 (Linking)
VI  - 64
IP  - Pt 1
DP  - 2000 Jan
TI  - Isolation, sequence, and chromosomal localisation of the human IkappaBR gene 
      (NFKBIL2).
PG  - 15-23
LID - 10.1017/S0003480000007910 [doi]
AB  - The inhibitors of NF-kappaB (IkappaBs) play an important role in the regulation 
      of the NF-kappaB pathway. IkappaBR (for IkappaB-Related) is proposed to be a 
      novel member of this family. We report the cloning and characterization of the 
      region of the human gene encoding the previously reported mRNA. This region 
      contains 13 exons, spread over 6550 bp of genomic sequence. The coding sequence 
      is only weakly similar to other IkappaBs and the exons display a more complicated 
      structure than has been found in other members of the IkappaB gene family. 
      Moreover, the positions of intron-exon junctions are different from those found 
      in other IkappaB genes, even within the otherwise conserved ankyrin-like repeat 
      region, suggesting that the IkappaBR gene is not a member of this extended gene 
      family. We report a revised mRNA and protein sequence for IkappaBR, which 
      predicts that the protein is larger than originally described. We also report the 
      chromosomal localisation of the human IkappaBR gene (approved gene symbol 
      NFKBIL2) to 8q24.3 using PCR-based somatic cell hybrid panel analysis and 
      fluorescence in situ hybridization (FISH) mapping.
FAU - Norman, D A
AU  - Norman DA
AD  - Cardiothoracic Surgery, National Heart & Lung Institute, Imperial College School 
      of Medicine, London, UK.
FAU - Barton, P J
AU  - Barton PJ
LA  - eng
SI  - GENBANK/AJ249601
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Hum Genet
JT  - Annals of human genetics
JID - 0416661
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (TONSL protein, human)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - *Chromosome Mapping
MH  - Chromosome Painting
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Conserved Sequence
MH  - DNA-Binding Proteins/genetics
MH  - Exons
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Introns
MH  - Mice
MH  - Molecular Sequence Data
MH  - NF-kappa B/*genetics/isolation & purification
MH  - Polymerase Chain Reaction
MH  - Promoter Regions, Genetic
MH  - Sequence Analysis, DNA
EDAT- 2001/03/14 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/03/14 10:00
PHST- 1999/10/19 00:00 [received]
PHST- 2001/03/14 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/03/14 10:00 [entrez]
AID - S0003480000007910 [pii]
AID - 10.1017/S0003480000007910 [doi]
PST - ppublish
SO  - Ann Hum Genet. 2000 Jan;64(Pt 1):15-23. doi: 10.1017/S0003480000007910.