PMID- 11248670
OWN - NLM
STAT- MEDLINE
DCOM- 20010503
LR  - 20161124
IS  - 0014-2956 (Print)
IS  - 0014-2956 (Linking)
VI  - 268
IP  - 6
DP  - 2001 Mar
TI  - Cyclin-dependent protein kinase 5 (Cdk5) and the regulation of neurofilament 
      metabolism.
PG  - 1534-46
AB  - Cyclin-dependent kinase 5 (Cdk5), a complex of Cdk5 and its activator p35 
      (Cdk5/p35), phosphorylates diverse substrates which have multifunctional roles in 
      the nervous system. During development, it participates in neuronal 
      differentiation, migration, axon outgrowth and synaptogenesis. Cdk5, acting 
      together with other kinases, phosphorylates numerous KSPXK consensus motifs in 
      diverse cytoskeletal protein target molecules, including neurofilaments, and 
      microtubule associated proteins, tau and MAPs. Phosphorylation regulates the 
      dynamic interactions of cytoskeletal proteins with one another during all aspects 
      of neurogenesis and axon radial growth. In this review we shall focus on Cdk5 and 
      its regulation as it modulates neurofilament metabolism in axon outgrowth, 
      cytoskeletal stabilization and radial growth. We suggest that Cdk5/p35 forms 
      compartmentalized macromolecular complexes of cytoskeletal substrates, other 
      neuronal kinases, phosphatases and activators ('phosphorylation machines') which 
      facilitate the dynamic molecular interactions that underlie these processes.
FAU - Grant, P
AU  - Grant P
AD  - Laboratory of Neurochemistry, National Institute of Neurological Disorders and 
      Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
FAU - Sharma, P
AU  - Sharma P
FAU - Pant, H C
AU  - Pant HC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Eur J Biochem
JT  - European journal of biochemistry
JID - 0107600
RN  - 0 (Nerve Tissue Proteins)
RN  - EC 2.7.11.1 (Cyclin-Dependent Kinase 5)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinases)
SB  - IM
MH  - Animals
MH  - Axons
MH  - Cyclin-Dependent Kinase 5
MH  - Cyclin-Dependent Kinases/genetics/*metabolism
MH  - Cytoskeleton/metabolism
MH  - Genes, Lethal
MH  - Nerve Tissue Proteins/*metabolism
MH  - Phosphorylation
RF  - 143
EDAT- 2001/03/15 10:00
MHDA- 2001/05/05 10:01
CRDT- 2001/03/15 10:00
PHST- 2001/03/15 10:00 [pubmed]
PHST- 2001/05/05 10:01 [medline]
PHST- 2001/03/15 10:00 [entrez]
AID - ejb2025 [pii]
PST - ppublish
SO  - Eur J Biochem. 2001 Mar;268(6):1534-46.