PMID- 11248805
OWN - NLM
STAT- MEDLINE
DCOM- 20010517
LR  - 20071108
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 1
IP  - 2
DP  - 2000 Aug
TI  - IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6.
PG  - 132-7
AB  - Overproduction of immunoglobulin E (IgE) and T helper cell type 2 (TH2) 
      cytokines, including interleukin 4 (IL-4), IL-5 and IL-13, can result in allergic 
      disorders. Although it is known that IL-4 is critical to the polarization of 
      naive CD4+ T cells to a TH2 phenotype, both in vitro and in many in vivo systems, 
      other factors that regulate in vivo IL-4 production and TH2 commitment are poorly 
      understood. IL-18, an IL-1-like cytokine that requires cleavage with caspase-1 to 
      become active, was found to increase IgE production in a CD4+ T cells-, IL-4- and 
      STAT6-dependent fashion. IL-18 and T cell receptor-mediated stimulation could 
      induce naive CD4+ T cells to develop into IL-4-producing cells in vitro. Thus, 
      caspase-1 and IL-18 may be critical in regulation of IgE production in vivo, 
      providing a potential therapeutic target for allergic disorders.
FAU - Yoshimoto, T
AU  - Yoshimoto T
AD  - Department of Immunology and Medical Zoology, Hyogo College of Medicine, 
      Nishinomiya, Hyogo, 663-8501, Japan.
FAU - Mizutani, H
AU  - Mizutani H
FAU - Tsutsui, H
AU  - Tsutsui H
FAU - Noben-Trauth, N
AU  - Noben-Trauth N
FAU - Yamanaka, K
AU  - Yamanaka K
FAU - Tanaka, M
AU  - Tanaka M
FAU - Izumi, S
AU  - Izumi S
FAU - Okamura, H
AU  - Okamura H
FAU - Paul, W E
AU  - Paul WE
FAU - Nakanishi, K
AU  - Nakanishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Interleukin-18)
RN  - 0 (Receptors, Interleukin-4)
RN  - 0 (STAT6 Transcription Factor)
RN  - 0 (STAT6 protein, human)
RN  - 0 (Stat6 protein, mouse)
RN  - 0 (Trans-Activators)
RN  - 147205-72-9 (CD40 Ligand)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.4.22.36 (Caspase 1)
SB  - IM
MH  - Animals
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - CD40 Ligand/genetics
MH  - Caspase 1/genetics/immunology
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Immunoglobulin E/*biosynthesis
MH  - Interleukin-18/genetics/*immunology
MH  - Interleukin-4/genetics/*immunology
MH  - Leprosy, Lepromatous/blood/immunology
MH  - Leprosy, Tuberculoid/blood/immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Receptors, Interleukin-4/genetics/immunology
MH  - STAT6 Transcription Factor
MH  - Th2 Cells/immunology/physiology
MH  - Trans-Activators/genetics/*immunology
EDAT- 2001/03/15 10:00
MHDA- 2001/05/18 10:01
CRDT- 2001/03/15 10:00
PHST- 2001/03/15 10:00 [pubmed]
PHST- 2001/05/18 10:01 [medline]
PHST- 2001/03/15 10:00 [entrez]
AID - 77811 [pii]
AID - 10.1038/77811 [doi]
PST - ppublish
SO  - Nat Immunol. 2000 Aug;1(2):132-7. doi: 10.1038/77811.