PMID- 11249508
OWN - NLM
STAT- MEDLINE
DCOM- 20010405
LR  - 20190915
IS  - 1465-6566 (Print)
IS  - 1465-6566 (Linking)
VI  - 1
IP  - 4
DP  - 2000 May
TI  - New anti-epileptic drugs for the 21st century.
PG  - 633-74
AB  - Prior to 1993, there were only six major drugs available in the US for the 
      treatment of patients with epilepsy. These included phenobarbital (PB), phenytoin 
      (PHT), carbamazepine (CBZ), primidone (PRIM), valproic acid/sodium valproate 
      (VPA) and ethosuximide (ESX). Of these drugs, VPA has the broadest spectrum of 
      activity and ESX the most limited. Despite these six agents, as well as several 
      secondary drugs, it is estimated that over 30% of patients have inadequate 
      seizure control, while others, whose disease is adequately controlled, suffer 
      from bothersome adverse events (AEs). Since 1993, ten new drugs have entered the 
      worldwide market (not all in the US). Those released include felbamate (FBM), 
      gabapentin (GBP), lamotrigine (LTG), topiramate (TPM), tiagabine (TGB), 
      oxcarbazepine (OXC), levetiracetam (LVT), zonisamide (ZNS), clobazam (CLB) and 
      vigabatrin (VGB). The purpose of this article is to review each of the above 
      drugs, looking at efficacy, safety, tolerability and where they may play a role 
      in the current treatment of epilepsy.
FAU - McCabe, P H
AU  - McCabe PH
AD  - Adult Comprehensive Epilepsy Treatment Center, Milton S Hershey Medical Center, 
      Pennsylvania State University College of Medicine, 500 University Drive, Hershey, 
      PA 17033, USA. pmccabe@psghs.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Expert Opin Pharmacother
JT  - Expert opinion on pharmacotherapy
JID - 100897346
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Animals
MH  - Anticonvulsants/adverse effects/economics/pharmacology/*therapeutic use
MH  - Clinical Trials as Topic
MH  - Epilepsy/*drug therapy/economics
MH  - Humans
RF  - 177
EDAT- 2001/03/16 10:00
MHDA- 2001/04/06 10:01
CRDT- 2001/03/16 10:00
PHST- 2001/03/16 10:00 [pubmed]
PHST- 2001/04/06 10:01 [medline]
PHST- 2001/03/16 10:00 [entrez]
AID - 10.1517/14656566.1.4.633 [doi]
PST - ppublish
SO  - Expert Opin Pharmacother. 2000 May;1(4):633-74. doi: 10.1517/14656566.1.4.633.