PMID- 11251480
OWN - NLM
STAT- MEDLINE
DCOM- 20010517
LR  - 20190831
IS  - 0160-564X (Print)
IS  - 0160-564X (Linking)
VI  - 25
IP  - 2
DP  - 2001 Feb
TI  - Effect of variation in systemic blood flow on plasma TNF-alpha in a pig model 
      with left ventricular assist device.
PG  - 146-50
AB  - Tumor necrosis factor-alpha (TNF-alpha) release has been implicated in a 
      sepsis-like syndrome following cardiopulmonary bypass (CPB). This also may be 
      important in patients who have had a left ventricular assist device (LVAD) 
      implanted. This report investigates the effect of reducing systemic blood flow on 
      hemodynamic response, mixed venous oxygen saturation (SvO(2)), and the release of 
      TNF-alpha. LVADs were implanted in 9 pigs. The aorta was clamped, and thus the 
      LVAD flow represented the entire systemic blood flow. Plasma TNF-alpha in the 
      femoral artery (FA) and superior mesenteric vein (SMV) was measured at baseline 
      and following systemic blood flow changes. Simultaneously, hemodynamic parameters 
      and oxygen saturation in the pulmonary artery (SvO(2)) were measured. Following 
      reductions in systemic blood flow, plasma TNF-alpha increased gradually to a 
      maximum level at a systemic blood flow of 20%. There was no significant 
      difference between TNF-alpha levels in the SMV and the FA. There was a 
      significant (p < 0.05) correlation between cardiac index, stroke volume index, 
      and TNF-alpha. The SvO(2) decreased significantly (p < 0.05) at a systemic blood 
      flow of 30 and 20%. A rise in TNF-alpha occurred when the SvO(2) was less than 
      75%. The data demonstrate that a reduction in systemic blood flow causes an 
      increase in plasma TNF-alpha. This can lead to the development of a sepsis-like 
      syndrome in a group of patients who already are hemodynamically compromised. 
      While weaning short-term LVAD support, rapid diminution of the cardiac output and 
      the pump flow must be avoided.
FAU - Uozaki, Y
AU  - Uozaki Y
AD  - First Department of Surgery, Toyama Medical and Pharmaceutical University, 
      Toyama, Japan. suginouo@pa.cff.nr.jp
FAU - Dihmis, W C
AU  - Dihmis WC
FAU - Yamauchi, H
AU  - Yamauchi H
FAU - Moczar, M
AU  - Moczar M
FAU - Miyama, M
AU  - Miyama M
FAU - Pasteau, F
AU  - Pasteau F
FAU - Tixier, D
AU  - Tixier D
FAU - Bambang, S L
AU  - Bambang SL
FAU - Loisance, D Y
AU  - Loisance DY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Artif Organs
JT  - Artificial organs
JID - 7802778
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Blood Flow Velocity
MH  - Disease Models, Animal
MH  - Heart Ventricles
MH  - *Heart-Assist Devices
MH  - Hemodynamics/*physiology
MH  - Oxygen/*blood
MH  - Probability
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
MH  - Swine
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 2001/03/17 10:00
MHDA- 2001/05/18 10:01
CRDT- 2001/03/17 10:00
PHST- 2001/03/17 10:00 [pubmed]
PHST- 2001/05/18 10:01 [medline]
PHST- 2001/03/17 10:00 [entrez]
AID - aor6544 [pii]
AID - 10.1046/j.1525-1594.2001.025002146.x [doi]
PST - ppublish
SO  - Artif Organs. 2001 Feb;25(2):146-50. doi: 10.1046/j.1525-1594.2001.025002146.x.