PMID- 11251859
OWN - NLM
STAT- MEDLINE
DCOM- 20010614
LR  - 20191104
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 12
IP  - 1
DP  - 2001 Feb
TI  - Exposure to a high concentration of mite allergen in early infancy is a risk 
      factor for developing atopic dermatitis: a 3-year follow-up study.
PG  - 11-6
AB  - The cause of allergy is multi-factorial, and the development of an allergic 
      disease seems to be the result of an interaction between genetic and 
      environmental factors. The goal for preventing the development of allergic 
      diseases is to avoid sensitization to allergens. The aim of this work was to 
      study whether or not exposure to environmental allergens early in infancy would 
      influence the occurence of various allergic diseases in later life. On an annual 
      basis, a total of 931 healthy newborns were followed-up until they reached 3 
      years of age. The occurence of allergic diseases was recorded by trained medical 
      students during visits. Measurement of Dermatophagoides pteronyssinus (Der p 1) 
      concentration in house dust was performed when each baby was 18 and 36 months 
      old. Total and specific immunoglobulin E (IgE) antibodies against Der p 1, cow's 
      milk, and egg white were evaluated at birth and at 18 months of age. The 
      following results were obtained: at 3 years of age, 10.4% had bronchial asthma 
      (BA), 21.4% atopic dermatitis (AD), 7.0% urticaria, and 46.8% had experienced 
      wheezing; higher family allergy scores led to a higher incidence of AD 
      (p=0.0012); exposure to a mite allergen concentration of 1 microg/g of dust may 
      be associated with a higher incidence of AD (p=0.0156); the presence of Der p 1 
      IgE antibody at 18 months of age was associated with a higher incidence of BA 
      (p=0.0001); and children sensitized to egg whites at 18 months of age had an 
      increased risk of developing AD at 3 years of age (p=0.0187). Hence, early 
      exposure to mite allergen is a risk factor for the development of atopic 
      dermatitis, but seems not to be related to the development of bronchial asthma. 
      Early sensitization to egg whites increases the risk of developing AD. The early 
      detection of serum Der p 1 IgE antibody is associated with a higher incidence of 
      bronchial asthma.
FAU - Huang, J L
AU  - Huang JL
AD  - Department of Pediatrics, Chang Gung Children's Hospital and Chang Gung 
      University, Taoyuan, Taiwan. long@adm.cgmh.com.tw
FAU - Chen, C C
AU  - Chen CC
FAU - Kuo, M L
AU  - Kuo ML
FAU - Hsieh, K H
AU  - Hsieh KH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 0 (Dust)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Allergens/*adverse effects
MH  - Animals
MH  - Asthma/blood
MH  - Child, Preschool
MH  - Dermatitis, Atopic/*etiology
MH  - Dust/adverse effects
MH  - Environmental Exposure/*adverse effects
MH  - Family Health
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunization/adverse effects
MH  - Immunoglobulin E/blood
MH  - Incidence
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Mites/*immunology
MH  - Risk Factors
EDAT- 2001/03/17 10:00
MHDA- 2001/06/15 10:01
CRDT- 2001/03/17 10:00
PHST- 2001/03/17 10:00 [pubmed]
PHST- 2001/06/15 10:01 [medline]
PHST- 2001/03/17 10:00 [entrez]
AID - pai033 [pii]
AID - 10.1034/j.1399-3038.2001.012001011.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2001 Feb;12(1):11-6. doi: 
      10.1034/j.1399-3038.2001.012001011.x.