PMID- 11252174
OWN - NLM
STAT- MEDLINE
DCOM- 20010823
LR  - 20071114
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 12
IP  - 3
DP  - 2001 Mar
TI  - Fine mapping of Hyplip1 and the human homolog, a potential locus for FCHL.
PG  - 238-45
AB  - Familial combined hyperlipidemia (FCHL) is a common genetic dyslipidemia 
      predisposing to premature coronary heart disease (CHD). We previously identified 
      a locus for FCHL on human Chromosome (Chr) 1q21-q23 in 31 Finnish FCHL families. 
      We also mapped a gene for combined hyperlipidemia (Hyplip1) to a potentially 
      orthologous region of mouse Chr 3 in the HcB-19/Dem mouse model of FCHL. The 
      human FCHL locus was, however, originally mapped about 5 Mb telomeric to the 
      synteny border, the centromeric part of which is homologous to mouse Chr 3 and 
      the telomeric part to mouse Chr 1. To further localize the human Hyplip1 homolog 
      and estimate its distance from the peak linkage markers, we fine-mapped the 
      Hyplip1 locus and defined the borders of the region of conserved synteny between 
      human and mouse. This involved establishing a physical map of a bacterial 
      artificial chromosome (BAC) contig across the Hyplip1 locus and hybridizing a set 
      of BACs to both human and mouse chromosomes by fluorescence in situ hybridization 
      (FISH). We narrowed the location of the mouse Hyplip1 gene to a 1.5-cM region 
      that is homologous only with human 1q21 and within approximately 5-10 Mb of the 
      peak marker for linkage to FCHL. FCHL is a complex disorder and this distance 
      may, thus, reflect the well-known problems hampering the mapping of complex 
      disorders. Further studies identifying and sequencing the Hyplip1 gene will show 
      whether the same gene predisposes to hyperlipidemia in human and mouse.
FAU - Pajukanta, P
AU  - Pajukanta P
AD  - UCLA, Department of Human Genetics, Gonda Neuroscience and Genetics Research 
      Center, Los Angeles, California 90095-7088, USA.
FAU - Bodnar, J S
AU  - Bodnar JS
FAU - Sallinen, R
AU  - Sallinen R
FAU - Chu, M
AU  - Chu M
FAU - Airaksinen, T
AU  - Airaksinen T
FAU - Xiao, Q
AU  - Xiao Q
FAU - Castellani, L W
AU  - Castellani LW
FAU - Sheth, S S
AU  - Sheth SS
FAU - Wessman, M
AU  - Wessman M
FAU - Palotie, A
AU  - Palotie A
FAU - Sinsheimer, J S
AU  - Sinsheimer JS
FAU - Demant, P
AU  - Demant P
FAU - Lusis, A J
AU  - Lusis AJ
FAU - Peltonen, L
AU  - Peltonen L
LA  - eng
GR  - CA16042/CA/NCI NIH HHS/United States
GR  - HL28481/HL/NHLBI NIH HHS/United States
GR  - HL42488/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
SB  - IM
MH  - Animals
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Bacterial
MH  - Contig Mapping
MH  - Humans
MH  - Hyperlipidemia, Familial Combined/*genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Microsatellite Repeats
EDAT- 2001/03/17 10:00
MHDA- 2001/08/24 10:01
CRDT- 2001/03/17 10:00
PHST- 2000/09/09 00:00 [received]
PHST- 2000/10/30 00:00 [accepted]
PHST- 2001/03/17 10:00 [pubmed]
PHST- 2001/08/24 10:01 [medline]
PHST- 2001/03/17 10:00 [entrez]
AID - 10.1007/s003350010265 [doi]
PST - ppublish
SO  - Mamm Genome. 2001 Mar;12(3):238-45. doi: 10.1007/s003350010265.