PMID- 11252654
OWN - NLM
STAT- MEDLINE
DCOM- 20010412
LR  - 20191104
IS  - 1398-5647 (Print)
IS  - 1398-5647 (Linking)
VI  - 2
IP  - 2
DP  - 2000 Jun
TI  - Can the expression of histocompatibility antigen be changed by lithium?
PG  - 140-4
AB  - OBJECTIVES: This study attempted to determine whether human leukocyte antigen 
      (HLA) type changes would be caused by lithium. METHODS: A total of 15 patients 
      were chosen as subjects (4 males, 11 females) and completed tests in class I. 
      Eight of the 15 patients completed tests in class II. Their mean age was 27 +/- 7 
      years. For an average of 51 +/- 17 days, lithium, 600-1,200 mg/day (mean daily 
      dose: 920 +/- 211 mg) was administered for the HLA testing and then compared with 
      the HLA type prior to the time the drug was administered. Class I type test was 
      performed according to the Terasaki microcytotoxicity method and class II type by 
      the Erlich polymerase chain reaction method. RESULTS: Of the 15 subjects, 11 had 
      changes in HLA-A, B, C types and two of the eight subjects had changes in HLA DR 
      type. CONCLUSION: Lithium, in the therapeutic dose, is considered to bring about 
      changes in HLA expressions in as short a time period as 2 months.
FAU - Kang, B J
AU  - Kang BJ
AD  - Department of Psychiatry, School of Medicine, Kyungpook National University, 
      Taegu, Korea. kuhpkbj@kyungpook.ac.kr
FAU - Park, S W
AU  - Park SW
FAU - Chung, T H
AU  - Chung TH
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
RN  - 0 (Antimanic Agents)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Lithium Compounds)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antimanic Agents/immunology/*pharmacology
MH  - Bipolar Disorder/*drug therapy/immunology
MH  - Dose-Response Relationship, Immunologic
MH  - Female
MH  - Gene Expression Regulation/*drug effects
MH  - HLA Antigens/*drug effects
MH  - HLA-A Antigens/drug effects
MH  - HLA-B Antigens/drug effects
MH  - HLA-C Antigens/drug effects
MH  - HLA-DR Antigens/drug effects
MH  - Humans
MH  - Lithium Compounds/immunology/*pharmacology
MH  - Male
MH  - Time Factors
EDAT- 2001/03/17 10:00
MHDA- 2001/04/17 10:01
CRDT- 2001/03/17 10:00
PHST- 2001/03/17 10:00 [pubmed]
PHST- 2001/04/17 10:01 [medline]
PHST- 2001/03/17 10:00 [entrez]
AID - 10.1034/j.1399-5618.2000.020208.x [doi]
PST - ppublish
SO  - Bipolar Disord. 2000 Jun;2(2):140-4. doi: 10.1034/j.1399-5618.2000.020208.x.