PMID- 11254361
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20071114
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 232
IP  - 1
DP  - 2001 Apr 1
TI  - Contribution of BDNF-mediated inhibition in patterning avian skin innervation.
PG  - 246-54
AB  - Multiple factors are involved in the development and regulation of sensory 
      innervation in skin. The findings we report here suggest that brain-derived 
      neurotrophic factor (BDNF)-mediated inhibition may play an important role in 
      determining the pattern of sensory innervation in avian skin. In birds, cutaneous 
      innervation is restricted to dermis, where axons form a ring of innervation 
      around the base of each feather. Here we show that both BDNF message and protein 
      are more abundant in avian epidermis than dermis when innervation is being 
      established; the BDNF in dermis is localized to feather buds. In vitro, BDNF 
      caused growth cones of NGF-dependent dorsal root ganglion neurons to collapse. 
      Similarly, outgrowth of neurites toward BDNF-secreting fibroblasts was inhibited. 
      The inhibitory effects of BDNF appear to be mediated by the low-affinity p75 
      neurotrophin receptor, rather than a trk receptor. Thus, the distribution of BDNF 
      in embryonic avian skin and the inhibitory effects of BDNF on cutaneous neurites 
      in vitro suggest that BDNF may be important in restricting axons from entering 
      the epidermis and the core of feather buds during development in vivo.
CI  - Copyright 2001 Academic Press.
FAU - Cahoon-Metzger, S M
AU  - Cahoon-Metzger SM
AD  - Department of Neurobiology and Anatomy, Program in Neuroscience, University of 
      Utah School of Medicine, 50 North Medical Drive, Salt Lake City, Utah, 84132, 
      USA.
FAU - Wang, G
AU  - Wang G
FAU - Scott, S A
AU  - Scott SA
LA  - eng
GR  - R01 NS16067/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Axons/physiology
MH  - Brain-Derived Neurotrophic Factor/analysis/*physiology
MH  - Chick Embryo
MH  - Coculture Techniques
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nerve Growth Factors/analysis
MH  - Neurites/physiology
MH  - Skin/*innervation
EDAT- 2001/03/20 10:00
MHDA- 2001/05/01 10:01
CRDT- 2001/03/20 10:00
PHST- 2001/03/20 10:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/03/20 10:00 [entrez]
AID - S0012-1606(01)90172-1 [pii]
AID - 10.1006/dbio.2001.0172 [doi]
PST - ppublish
SO  - Dev Biol. 2001 Apr 1;232(1):246-54. doi: 10.1006/dbio.2001.0172.