PMID- 11254667
OWN - NLM
STAT- MEDLINE
DCOM- 20010419
LR  - 20240314
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 107
IP  - 6
DP  - 2001 Mar
TI  - Hyperhomocysteinemia enhances vascular inflammation and accelerates 
      atherosclerosis in a murine model.
PG  - 675-83
AB  - Although hyperhomocysteinemia (HHcy) is a well-known risk factor for the 
      development of cardiovascular disease, the underlying molecular mechanisms are 
      not fully elucidated. Here we show that induction of HHcy in apoE-null mice by a 
      diet enriched in methionine but depleted in folate and vitamins B6 and B12 
      increased atherosclerotic lesion area and complexity, and enhanced expression of 
      receptor for advanced glycation end products (RAGE), VCAM-1, tissue factor, and 
      MMP-9 in the vasculature. These homocysteine-mediated (HC-mediated) effects were 
      significantly suppressed, in parallel with decreased levels of plasma HC, upon 
      dietary supplementation with folate and vitamins B6/B12. These findings implicate 
      HHcy in atherosclerotic plaque progression and stability, and they suggest that 
      dietary enrichment in vitamins essential for the metabolism of HC may impart 
      protective effects in the vasculature.
FAU - Hofmann, M A
AU  - Hofmann MA
AD  - College of Physicians and Surgeons, Columbia University, 630 W. 168th Street, P&S 
      17-501, New York, NY 10032, USA. mah81@columbia.edu
FAU - Lalla, E
AU  - Lalla E
FAU - Lu, Y
AU  - Lu Y
FAU - Gleason, M R
AU  - Gleason MR
FAU - Wolf, B M
AU  - Wolf BM
FAU - Tanji, N
AU  - Tanji N
FAU - Ferran, L J Jr
AU  - Ferran LJ Jr
FAU - Kohl, B
AU  - Kohl B
FAU - Rao, V
AU  - Rao V
FAU - Kisiel, W
AU  - Kisiel W
FAU - Stern, D M
AU  - Stern DM
FAU - Schmidt, A M
AU  - Schmidt AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Apolipoproteins E)
RN  - 0 (Receptor for Advanced Glycation End Products)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 9035-58-9 (Thromboplastin)
RN  - 935E97BOY8 (Folic Acid)
RN  - AE28F7PNPL (Methionine)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - KV2JZ1BI6Z (Pyridoxine)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
CIN - J Clin Invest. 2001 Mar;107(6):663-4. PMID: 11254663
MH  - Animals
MH  - Apolipoproteins E/deficiency/genetics
MH  - Arteriosclerosis/*etiology/metabolism/pathology
MH  - Cells, Cultured
MH  - Diet
MH  - Disease Models, Animal
MH  - Folic Acid/administration & dosage
MH  - Humans
MH  - Hyperhomocysteinemia/*complications/metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Matrix Metalloproteinase 9/metabolism
MH  - Methionine/administration & dosage
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Pyridoxine/administration & dosage
MH  - Receptor for Advanced Glycation End Products
MH  - Receptors, Immunologic/metabolism
MH  - Thromboplastin/metabolism
MH  - Vascular Cell Adhesion Molecule-1/metabolism
MH  - Vasculitis/*etiology/metabolism/pathology
MH  - Vitamin B 12/administration & dosage
PMC - PMC208940
EDAT- 2001/03/20 10:00
MHDA- 2001/04/21 10:01
PMCR- 2001/03/15
CRDT- 2001/03/20 10:00
PHST- 2001/03/20 10:00 [pubmed]
PHST- 2001/04/21 10:01 [medline]
PHST- 2001/03/20 10:00 [entrez]
PHST- 2001/03/15 00:00 [pmc-release]
AID - 10588 [pii]
AID - 10.1172/JCI10588 [doi]
PST - ppublish
SO  - J Clin Invest. 2001 Mar;107(6):675-83. doi: 10.1172/JCI10588.