PMID- 11254909
OWN - NLM
STAT- MEDLINE
DCOM- 20010621
LR  - 20190718
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 155
IP  - 2
DP  - 2001 Apr
TI  - Effects of heparin and aspirin on circulating P-selectin, E-selectin and von 
      Willebrand Factor levels in healthy men.
PG  - 389-93
AB  - As thrombin stimulates P-selectin expression on platelets and its release into 
      plasma, we hypothesized that enhancing antithrombin activity by unfractionated 
      heparin (UFH) could decrease plasma levels of circulating (c)P-selectin, 
      (c)E-selectin, and von Willebrand Factor (vWF). Hence the effect of UFH and 
      aspirin were examined on these activation markers in healthy volunteers. UFH 
      decreased cP-selectin levels by -10% (CI: -16 - (-4%); P = 0.005) at 24 h, but 
      did not change levels of vWF-Ag. In contrast, aspirin did not affect cP-selectin 
      levels but decreased vWF-Ag levels by -12% (CI: -18 - (-7%); P = 0.005) at 24 h. 
      Neither drug affected cE-selectin levels. Thus, UFH decreases cP-selectin levels, 
      which may reflect decreased platelet activation in vivo. An increase in 
      cP-selectin under UFH therapy should alert the clinician to look for platelet 
      destruction.
FAU - Pernerstorfer, T
AU  - Pernerstorfer T
AD  - Department of Clinical Pharmacology-TARGET, Vienna University Hospital School of 
      Medicine, Wahringer Gurtel, A-1090, Vienna, Austria.
FAU - Eichler, H G
AU  - Eichler HG
FAU - Stohlawetz, P
AU  - Stohlawetz P
FAU - Speiser, W
AU  - Speiser W
FAU - Jilma, B
AU  - Jilma B
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (Anticoagulants)
RN  - 0 (Biomarkers)
RN  - 0 (E-Selectin)
RN  - 0 (P-Selectin)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (von Willebrand Factor)
RN  - 9005-49-6 (Heparin)
RN  - EC 3.4.21.5 (Thrombin)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Adult
MH  - Anticoagulants/*pharmacology
MH  - Aspirin/*pharmacology
MH  - Biomarkers
MH  - E-Selectin/*blood
MH  - Heparin/*pharmacology
MH  - Humans
MH  - Male
MH  - P-Selectin/*blood
MH  - Partial Thromboplastin Time
MH  - Platelet Aggregation Inhibitors/*pharmacology
MH  - Reference Values
MH  - Thrombin/*antagonists & inhibitors
MH  - von Willebrand Factor/*analysis
EDAT- 2001/03/20 10:00
MHDA- 2001/06/22 10:01
CRDT- 2001/03/20 10:00
PHST- 2001/03/20 10:00 [pubmed]
PHST- 2001/06/22 10:01 [medline]
PHST- 2001/03/20 10:00 [entrez]
AID - S0021-9150(00)00566-9 [pii]
AID - 10.1016/s0021-9150(00)00566-9 [doi]
PST - ppublish
SO  - Atherosclerosis. 2001 Apr;155(2):389-93. doi: 10.1016/s0021-9150(00)00566-9.