PMID- 11255328
OWN - NLM
STAT- MEDLINE
DCOM- 20010405
LR  - 20220409
IS  - 0003-987X (Print)
IS  - 0003-987X (Linking)
VI  - 137
IP  - 3
DP  - 2001 Mar
TI  - Association of human herpesvirus 6 infection with drug reaction with eosinophilia 
      and systemic symptoms.
PG  - 301-4
AB  - BACKGROUND: There is a current debate regarding the association of human 
      herpesvirus 6 (HHV-6) infection and drug reaction with eosinophilia and systemic 
      symptoms (DRESS). METHODS: Seven consecutive patients hospitalized with DRESS 
      were enrolled in a prospective study to evaluate evidence of active HHV-6 
      infection. OBSERVATIONS: The imputable drugs were carbamazepine (5 patients), 
      ibuprofen (1 patient), and sulfasalazine (1 patient). All patients were 
      seropositive for anti-HHV-6 IgG antibodies. Anti-HHV-6 IgM antibodies were 
      detected in 4 of the 7 patients with a seroconversion in 2 patients. Neither 
      anti-cytomegalovirus nor anti-Epstein-Barr virus early antigen IgM antibody was 
      detected. Human herpesvirus 6 genome was not detected by polymerase chain 
      reaction in the first serum sample of all patients. It was weakly detected in 
      skin lesions in the last patient tested by polymerase chain reaction but was not 
      found in uninvolved skin. CONCLUSIONS: The results suggest an association between 
      HHV-6 active infection (primo-infection or reactivation) and severe DRESS. 
      Absence of anti-cytomegalovirus or anti-Epstein-Barr virus early antigen IgM 
      antibodies argues against a nonspecific viral reactivation. Human herpesvirus 6 
      infection may play a role in the development of DRESS in susceptible patients. 
      Some drugs with reactive metabolites could favor reactivation and propagation of 
      HHV-6.
FAU - Descamps, V
AU  - Descamps V
AD  - Dermatology Department, Hopital Bichat-Claude Bernard, 46 rue Henri Huchard, 
      75018 Paris, France. vincent.descamps@bch.ap-hop-paris.fr
FAU - Valance, A
AU  - Valance A
FAU - Edlinger, C
AU  - Edlinger C
FAU - Fillet, A M
AU  - Fillet AM
FAU - Grossin, M
AU  - Grossin M
FAU - Lebrun-Vignes, B
AU  - Lebrun-Vignes B
FAU - Belaich, S
AU  - Belaich S
FAU - Crickx, B
AU  - Crickx B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arch Dermatol
JT  - Archives of dermatology
JID - 0372433
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulin M)
RN  - 33CM23913M (Carbamazepine)
RN  - 3XC8GUZ6CB (Sulfasalazine)
RN  - WK2XYI10QM (Ibuprofen)
SB  - IM
CIN - Arch Dermatol. 2001 Mar;137(3):357-64. PMID: 11255340
CIN - Arch Dermatol. 2002 Feb;138(2):268-9. PMID: 11843657
MH  - Adult
MH  - Antibodies, Viral/blood
MH  - Carbamazepine/adverse effects
MH  - DNA, Viral/analysis
MH  - Drug Eruptions/complications/*virology
MH  - Eosinophilia/complications/*virology
MH  - Herpesviridae Infections/*complications/virology
MH  - *Herpesvirus 6, Human/immunology/isolation & purification
MH  - Humans
MH  - Ibuprofen/adverse effects
MH  - Immunoglobulin G/blood
MH  - Immunoglobulin M/blood
MH  - Prospective Studies
MH  - Skin/virology
MH  - Sulfasalazine/adverse effects
MH  - Syndrome
EDAT- 2001/03/20 10:00
MHDA- 2001/04/06 10:01
CRDT- 2001/03/20 10:00
PHST- 2001/03/20 10:00 [pubmed]
PHST- 2001/04/06 10:01 [medline]
PHST- 2001/03/20 10:00 [entrez]
AID - dob9037 [pii]
PST - ppublish
SO  - Arch Dermatol. 2001 Mar;137(3):301-4.