PMID- 11256751
OWN - NLM
STAT- MEDLINE
DCOM- 20010621
LR  - 20191104
IS  - 0940-2993 (Print)
IS  - 0940-2993 (Linking)
VI  - 52
IP  - 6
DP  - 2001 Feb
TI  - Apoptosis in mouse fetuses from dams exposed to T-2 toxin at different days of 
      gestation.
PG  - 493-501
AB  - T-2 toxin (2 mg/kg b.w.) was orally inoculated to pregnant mice at gestational 
      day (GD) 8.5, 9.5, 10.5, 11.5, 12.5, 13.5, 14.5, 15.5 and GD 16.5, respectively, 
      and the fetuses were examined 24 hours later. The number and region of pyknotic 
      or karyorrhectic cells varied according to inoculation date. In the GD 
      13.5-subgroup, a moderate to high number of pyknotic or karyorrhectic neuronal 
      cells were observed in the central nervous system, peri-ventricular zone to 
      subventricular zone, and pyknosis or karyorrhexis were also observed in a small 
      number of chondroblasts and chondrocytes. In the GD 16.5-subgroup, a moderate to 
      high number of pyknotic or karyorrhectic cells were observed in the thymus and 
      renal subcapsular parenchyma. The nuclei of these pyknotic or karyorrhectic cells 
      were strongly stained by the terminal deoxy nucleotidyl transferase 
      (TdT)-mediated dUTP-digoxigenin nick end labeling method widely used for the in 
      situ detection of apoptotic nuclei. In addition, a few fetuses from dams which 
      were given T-2 toxin at GD 13.5 or GD 14.5 and killed at GD 17.5 showed skeletal 
      abnormalities such as wavy ribs and short scapula. From the present findings and 
      the well known fact that T-2 toxin readily crosses the rat placenta, it seems 
      that T-2 toxin-induced apoptosis in the developing mouse fetuses might be a 
      direct effect of T-2 toxin on fetuses.
FAU - Ishigami, N
AU  - Ishigami N
AD  - Department of Veterinary Pathology, Faculty of Agriculture, The University of 
      Tokyo, Japan. aa77/45@mail.ecc.u-tokyo.ac.jp
FAU - Shinozuka, J
AU  - Shinozuka J
FAU - Katayama, K
AU  - Katayama K
FAU - Nakayama, H
AU  - Nakayama H
FAU - Doi, K
AU  - Doi K
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Exp Toxicol Pathol
JT  - Experimental and toxicologic pathology : official journal of the Gesellschaft fur 
      Toxikologische Pathologie
JID - 9208920
RN  - 0 (Proliferating Cell Nuclear Antigen)
RN  - I3FL5NM3MO (T-2 Toxin)
SB  - IM
MH  - Abnormalities, Drug-Induced
MH  - Administration, Oral
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - Bone and Bones/abnormalities/drug effects
MH  - Central Nervous System/abnormalities/drug effects
MH  - Embryonic and Fetal Development/drug effects
MH  - Female
MH  - Fetal Death/chemically induced
MH  - Fetal Weight/drug effects
MH  - Fetus/*drug effects/metabolism
MH  - Immunoenzyme Techniques
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Pregnancy
MH  - Proliferating Cell Nuclear Antigen/metabolism
MH  - Ribs/abnormalities/drug effects
MH  - Scapula/abnormalities/drug effects
MH  - T-2 Toxin/administration & dosage/*toxicity
MH  - Time Factors
EDAT- 2001/03/21 10:00
MHDA- 2001/06/22 10:01
CRDT- 2001/03/21 10:00
PHST- 2001/03/21 10:00 [pubmed]
PHST- 2001/06/22 10:01 [medline]
PHST- 2001/03/21 10:00 [entrez]
AID - 10.1016/s0940-2993(01)80004-x [doi]
PST - ppublish
SO  - Exp Toxicol Pathol. 2001 Feb;52(6):493-501. doi: 10.1016/s0940-2993(01)80004-x.