PMID- 11257279
OWN - NLM
STAT- MEDLINE
DCOM- 20010531
LR  - 20190718
IS  - 0021-9150 (Print)
IS  - 0021-9150 (Linking)
VI  - 154
IP  - 3
DP  - 2001 Feb 15
TI  - Chromosomal alterations in atherosclerotic plaques.
PG  - 755-61
AB  - Alterations of chromosomes 7 and 11 have been involved in the progression of 
      atherosclerosis. Twenty-three carotid endarterectomy specimens were studied for 
      the presence of alterations in chromosomes 7 and 11, and fibroblastic growth 
      factor-3 (FGF-3) gene amplification. Besides classic histological stainings, 
      immunophenotyping of cellular and vascular components and fluorescence in situ 
      hybridization (FISH) were performed. At the caps, unstable plaques (n=18) showed 
      inflammatory infiltration of macrophages, smooth muscle cells, and T-lymphocytes. 
      Specifically in these regions, the FISH showed varying percentages of trisomy 
      (15/18) and tetrasomy (8/15) of chromosome 7. In four cases polisomy 7 was noted 
      in some nuclei. Monosomy of chromosome 11 and gene amplification of FGF-3 gene 
      was observed. The FISH of the five stable plaques and normal arterial walls 
      showed no chromosome alterations; furthermore, chromosome 3, which is not 
      involved in atherosclerotic progression, presented a normal ploidy of smooth 
      muscle cells in stable and unstable plaques and normal arterial walls. In 
      conclusion, chromosome 7 and 11 alterations and FGF-3 gene amplification are 
      components of unstable plaques, and might contribute to the evolution of stable 
      plaques into complicated plaques.
FAU - Matturri, L
AU  - Matturri L
AD  - Institute of Pathology, University of Milan, Ospedale Maggiore, IRCCS, Milan, 
      Italy.
FAU - Cazzullo, A
AU  - Cazzullo A
FAU - Turconi, P
AU  - Turconi P
FAU - Lavezzi, A M
AU  - Lavezzi AM
FAU - Vandone, P L
AU  - Vandone PL
FAU - Gabrielli, L
AU  - Gabrielli L
FAU - Fernandez Alonso, G
AU  - Fernandez Alonso G
FAU - Grana, D
AU  - Grana D
FAU - Milei, J
AU  - Milei J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (FGF3 protein, human)
RN  - 0 (Fibroblast Growth Factor 3)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Arteriosclerosis/*genetics/pathology
MH  - Carotid Arteries/pathology/physiopathology
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Chromosomes, Human, Pair 7/*genetics
MH  - Female
MH  - Fibroblast Growth Factor 3
MH  - Fibroblast Growth Factors/genetics
MH  - Gene Amplification
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins/genetics
EDAT- 2001/03/21 10:00
MHDA- 2001/06/02 10:01
CRDT- 2001/03/21 10:00
PHST- 2001/03/21 10:00 [pubmed]
PHST- 2001/06/02 10:01 [medline]
PHST- 2001/03/21 10:00 [entrez]
AID - S0021-9150(00)00488-3 [pii]
AID - 10.1016/s0021-9150(00)00488-3 [doi]
PST - ppublish
SO  - Atherosclerosis. 2001 Feb 15;154(3):755-61. doi: 10.1016/s0021-9150(00)00488-3.