PMID- 11258612
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20191104
IS  - 1091-6660 (Print)
IS  - 1091-6660 (Linking)
VI  - 5
IP  - 1
DP  - 2001 Feb
TI  - Allogeneic peripheral blood stem cell transplantation for severe aplastic anemia.
PG  - 54-7
AB  - Allogeneic peripheral blood stem cell transplantation (PBSCT) is rarely applied 
      for the treatment of severe aplastic anemia (SAA) because of questionable 
      durability of engraftment and increased risk of graft versus host disease (GVHD). 
      We performed allogeneic PBSCT in 3 SAA patients from their human leukocyte 
      antigen (HLA)-identical siblings. One received bone marrow after conditioning 
      with cyclophoshamide (Cy) plus antithymocyte globulin. He had a second transplant 
      with peripheral blood stem cells from the original donor because of a graft 
      failure (GF). Two other patients received PBSCT as a first option, with Cy as the 
      only conditioning drug. The 3 patients received short-term methotrexate and 
      cyclosporine as a postgrafting immunosupression. In the latter 2 cases, no GF has 
      been observed, and a successful and complete hematological recovery was achieved 
      and maintained for 28 and 25 months, respectively. In conclusion, PBSCT provides 
      a quick and complete hematological recovery in SAA patients.
FAU - Gurman, G
AU  - Gurman G
AD  - Department of Hematology, Ankara University Medical School, Ibn-i Sina Hospital, 
      Turkey. gurman@medicine2.ankara.edu.tr
FAU - Celebi, H
AU  - Celebi H
FAU - Ustun, C
AU  - Ustun C
FAU - Arat, M
AU  - Arat M
FAU - Ilhan, O
AU  - Ilhan O
FAU - Ozcan, M
AU  - Ozcan M
FAU - Arslan, O
AU  - Arslan O
FAU - Uysal, A
AU  - Uysal A
FAU - Akan, H
AU  - Akan H
FAU - Beksac, M
AU  - Beksac M
FAU - Konuk, N
AU  - Konuk N
FAU - Koc, H
AU  - Koc H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Ther Apher
JT  - Therapeutic apheresis : official journal of the International Society for 
      Apheresis and the Japanese Society for Apheresis
JID - 9706703
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anemia, Aplastic/*therapy
MH  - Fatal Outcome
MH  - Graft vs Host Disease/etiology
MH  - Humans
MH  - Leukapheresis
MH  - Male
MH  - *Stem Cell Transplantation
MH  - Transplantation, Homologous
EDAT- 2001/03/22 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/03/22 10:00
PHST- 2001/03/22 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/03/22 10:00 [entrez]
AID - 10.1046/j.1526-0968.2001.005001054.x [doi]
PST - ppublish
SO  - Ther Apher. 2001 Feb;5(1):54-7. doi: 10.1046/j.1526-0968.2001.005001054.x.