PMID- 11259807
OWN - NLM
STAT- MEDLINE
DCOM- 20010607
LR  - 20191210
IS  - 0167-5273 (Print)
IS  - 0167-5273 (Linking)
VI  - 78
IP  - 1
DP  - 2001 Mar
TI  - Early expression of natriuretic peptides and SERCA in mild heart failure: 
      association with severity of the disease.
PG  - 5-12
AB  - BACKGROUND: We investigated changes in genetic expression of atrial and brain 
      natriuretic peptides (ANP and BNP) and sarcoplasmic reticulum Ca(2+)-ATPase 
      (SERCA) in patients with stable mild to moderate chronic heart failure (CHF), 
      since data on this topic were primarily obtained in end-stage CHF. METHODS: We 
      studied tissue from 25 patients with idiopathic dilated cardiomyopathy (IDC) in 
      New York Heart Association (NYHA) class II (n=12) and III-IV (n=13). Myocardial 
      tissue from normal hearts (n=10) served as controls. Messenger RNA (mRNA) 
      expression of ANP, BNP, and SERCA was isolated, and correlated with severity of 
      CHF, left ventricular function (LVEF), peak oxygen uptake (peak VO(2)), and wedge 
      pressure. RESULTS: A significant trend for gradual changes in mRNA expression 
      according to increasing NYHA class was found for ANP, BNP (P<0.0001) and SERCA 
      (P=0.04), with a marked increase in patients with more advanced CHF (ANP and BNP: 
      P<0.01 vs. controls; SERCA: NS) and less pronounced changes in patients with mild 
      CHF. mRNA of ANP and BNP correlated strongly with LVEF (-0.621 and -0.621, 
      respectively, both P<0.01) and peak VO(2) (-0.625 and -0.555, respectively, both 
      P<0.01) and, to a lesser extent, with wedge pressure (0.440 and 0.488, 
      respectively, both P<0.05). SERCA correlated most strongly with wedge pressure 
      (-0.623, P<0.01), and weak, non-significant correlations with LVEF and peak VO(2) 
      were found. CONCLUSIONS: Genetic expression of ANP, BNP, and SERCA is 
      progressively altered in proportion to the severity of CHF, although this is more 
      marked for ANP and to a lesser extent BNP, than for SERCA. These changes support 
      the concept that already early in CHF, genetic expression is affected, which has 
      implications for the understanding of the pathophysiology of CHF.
FAU - de Boer, R A
AU  - de Boer RA
AD  - Thoraxcenter, Department of Cardiology, University Hospital, P.O. Box 30.001, 
      9700 RB, Groningen, The Netherlands. r.a.de.boer@thorax.azg.nl
FAU - Henning, R H
AU  - Henning RH
FAU - Suurmeijer, A J
AU  - Suurmeijer AJ
FAU - Pinto, Y M
AU  - Pinto YM
FAU - Olthof, E
AU  - Olthof E
FAU - Kirkels, J H
AU  - Kirkels JH
FAU - van Gilst, W H
AU  - van Gilst WH
FAU - Crijns, H J
AU  - Crijns HJ
FAU - van Veldhuisen, D J
AU  - van Veldhuisen DJ
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (RNA, Messenger)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - EC 3.6.3.8 (Sarcoplasmic Reticulum Calcium-Transporting ATPases)
RN  - EC 7.2.2.10 (Calcium-Transporting ATPases)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Atrial Natriuretic Factor/*metabolism
MH  - Calcium-Transporting ATPases/*metabolism
MH  - Cardiomyopathy, Dilated/*blood/physiopathology
MH  - Disease Progression
MH  - Female
MH  - *Gene Expression
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Sarcoplasmic Reticulum Calcium-Transporting ATPases
MH  - Severity of Illness Index
EDAT- 2001/03/22 10:00
MHDA- 2001/06/08 10:01
CRDT- 2001/03/22 10:00
PHST- 2001/03/22 10:00 [pubmed]
PHST- 2001/06/08 10:01 [medline]
PHST- 2001/03/22 10:00 [entrez]
AID - S016752730000440X [pii]
AID - 10.1016/s0167-5273(00)00440-x [doi]
PST - ppublish
SO  - Int J Cardiol. 2001 Mar;78(1):5-12. doi: 10.1016/s0167-5273(00)00440-x.