PMID- 11260333
OWN - NLM
STAT- MEDLINE
DCOM- 20010927
LR  - 20220408
IS  - 0919-8172 (Print)
IS  - 0919-8172 (Linking)
VI  - 8
IP  - 3
DP  - 2001 Mar
TI  - Transurethral needle ablation of the prostate: an initial Japanese clinical 
      trial.
PG  - 99-105
AB  - OBJECTIVES: Transurethral needle ablation of the prostate is a new alternative 
      endoscopic thermal therapy that uses a low-energy radio frequency delivered into 
      the prostatic adenoma. Herein is reported the initial clinical experience by 
      multiple institutes in Japan of transurethral needle ablation of the prostate for 
      the treatment of symptomatic benign prostatic hyperplasia. METHODS: A total of 93 
      patients were treated with this technique. Transurethral needle ablation of the 
      prostate was generally performed under low-spinal anesthesia. Before and after 
      the procedure, international symptom score (IPSS), quality of life (QOL) score, 
      peak urinary flow rate (Qmax), postvoid residual urine volume and prostate size 
      were evaluated. RESULTS: There was a reduction of IPSS of more than 50% when 
      compared with that of pretreatment, being 51.3% (57/93 patients) and 60.2% (56/93 
      patients) at 3 months and 6 months after the procedure, respectively. Sixty-seven 
      patients who were available for a 12-month follow-up period demonstrated a 
      markedly decreased mean IPSS when compared with that measured before the 
      treatment for a statistically significant difference (P < 0.01). Fifty-eight 
      patients who were available for uroflowmetric study at 12 months exhibited a 
      notably increased mean Qmax of 11.2 +/- 4.5 mL/s, which was a statistically 
      significant increase when compared with that found before treatment (P < 0.05). 
      Although all patients suffered some degree of gross hematuria after the 
      procedure, none of them required any specific treatment for complications. 
      CONCLUSION: Transurethral needle ablation technique for the treatment of 
      symptomatic benign prostatic hyperplasia is safe and effective. However, a much 
      longer follow-up study is essential for fully evaluating the extended 
      effectiveness of this technique.
FAU - Murai, M
AU  - Murai M
AD  - Departments of Urology, School of Medicine, Keio University, Tokyo, Tokyo Medical 
      University, Tokyo, and Nara Medical University, Nara, Japan. 
      mmurai@med.keio.ac.jp
FAU - Tachibana, M
AU  - Tachibana M
FAU - Miki, M
AU  - Miki M
FAU - Shiozawa, H
AU  - Shiozawa H
FAU - Hirao, Y
AU  - Hirao Y
FAU - Okajima, E
AU  - Okajima E
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Australia
TA  - Int J Urol
JT  - International journal of urology : official journal of the Japanese Urological 
      Association
JID - 9440237
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Catheter Ablation
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Needles
MH  - Prostatic Hyperplasia/complications/diagnosis/physiopathology/*surgery
MH  - Quality of Life
MH  - Urethra
MH  - Urodynamics
EDAT- 2001/03/22 10:00
MHDA- 2001/09/28 10:01
CRDT- 2001/03/22 10:00
PHST- 2001/03/22 10:00 [pubmed]
PHST- 2001/09/28 10:01 [medline]
PHST- 2001/03/22 10:00 [entrez]
AID - iju260 [pii]
AID - 10.1046/j.1442-2042.2001.00260.x [doi]
PST - ppublish
SO  - Int J Urol. 2001 Mar;8(3):99-105. doi: 10.1046/j.1442-2042.2001.00260.x.