PMID- 11260607
OWN - NLM
STAT- MEDLINE
DCOM- 20010719
LR  - 20191210
IS  - 0197-3851 (Print)
IS  - 0197-3851 (Linking)
VI  - 21
IP  - 3
DP  - 2001 Mar
TI  - Assessment of fetal status in multiple gestation pregnancies using interphase 
      FISH.
PG  - 196-9
AB  - The use of fluorescence in situ hybridization (FISH) for women with multiple 
      gestation pregnancies has been evaluated. Women were referred for chromosome 
      analysis because of advanced maternal age, abnormal ultrasound findings or a 
      positive family history and/or prior to fetal reduction. FISH was successfully 
      applied to all specimens obtained by amniocentesis or chorionic villus sampling 
      (CVS). Based on FISH results, fetal-fetal contamination of specimens following 
      CVS was 11.5% in twin pregnancies and 16% in triplet or higher multiples. FISH 
      detected trisomy 21 in three cases with no false negatives or positives. Whereas 
      FISH may provide rapid and useful assessment of fetal status in decision-making 
      regarding fetal reduction, the present study also highlighted the obstetrical 
      difficulty of ensuring a sample representative of each fetus following CVS in 
      addition to the possibility of not identifying clinically significant chromosome 
      aberrations using currently available FISH probes.
CI  - Copyright 2001 John Wiley & Sons, Ltd.
FAU - Fiddler, M
AU  - Fiddler M
AD  - DePaul University, School for New Learning, 25 East Jackson Boulevard, Chicago, 
      IL 60604, USA.
FAU - Frederickson, M C
AU  - Frederickson MC
FAU - Chen, P X
AU  - Chen PX
FAU - Pergament, E
AU  - Pergament E
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Prenat Diagn
JT  - Prenatal diagnosis
JID - 8106540
SB  - IM
MH  - Amniotic Fluid/cytology
MH  - Chromosome Aberrations/*diagnosis
MH  - Chromosome Disorders
MH  - Female
MH  - Fetal Diseases/*diagnosis
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Interphase
MH  - Predictive Value of Tests
MH  - Pregnancy
MH  - *Pregnancy, Multiple
MH  - *Prenatal Diagnosis/methods
EDAT- 2001/03/22 10:00
MHDA- 2001/07/20 10:01
CRDT- 2001/03/22 10:00
PHST- 2001/03/22 10:00 [pubmed]
PHST- 2001/07/20 10:01 [medline]
PHST- 2001/03/22 10:00 [entrez]
AID - 10.1002/1097-0223(200103)21:3<196::AID-PD26>3.0.CO;2-I [pii]
AID - 10.1002/1097-0223(200103)21:3<196::aid-pd26>3.0.co;2-i [doi]
PST - ppublish
SO  - Prenat Diagn. 2001 Mar;21(3):196-9. doi: 
      10.1002/1097-0223(200103)21:3<196::aid-pd26>3.0.co;2-i.