PMID- 11260880
OWN - NLM
STAT- MEDLINE
DCOM- 20010521
LR  - 20201208
IS  - 0387-5911 (Print)
IS  - 0387-5911 (Linking)
VI  - 75
IP  - 2
DP  - 2001 Feb
TI  - [Suppressive effect of lansoprazole on anti-Candida activity of murine 
      macrophages].
PG  - 137-43
AB  - This study investigated the influences of lansoprazole (AG1749), a proton pump 
      inhibitor (PPI), and its active derivative (AG2000) on Candida albicans growth 
      and the anti-Candida activity of macrophages. Under concentration of 100 microM, 
      AG1749 and AG2000 had no effect on Candida growth. Murine peritoneal macrophages 
      inhibited the growth of C. albicans in vitro. AG2000 suppressed the anti-Candida 
      activity of macrophages dose-dependently, but AG1749 didn't. The suppressing 
      activity of AG2000 for macrophages was neutralized by adding a SH-compound 
      (L-cysteine) in the medium. This suggests that AG2000 may suppress macrophage 
      function in a similar manner with inhibition of proton pump through binding to 
      SH-molecules. When macrophages were preincubated with AG2000 for 1 hr and washed, 
      their anti-Candida activity remained to be partially inhibited for 14 hrs. These 
      results were discussed in relation to the pathogenesis of esophageal candidiasis.
FAU - Motegi, H
AU  - Motegi H
AD  - Department of Internal Medicine, Teikyo University School of Medicine.
FAU - Abe, S
AU  - Abe S
FAU - Tansho, S
AU  - Tansho S
FAU - Suzuki, D
AU  - Suzuki D
FAU - Yamaguchi, H
AU  - Yamaguchi H
FAU - Hoshino, E
AU  - Hoshino E
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Kansenshogaku Zasshi
JT  - Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious 
      Diseases
JID - 0236671
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Animals
MH  - Candida albicans/*growth & development
MH  - Cells, Cultured
MH  - Female
MH  - Lansoprazole
MH  - Macrophages, Peritoneal/drug effects/*microbiology
MH  - Mice
MH  - Omeprazole/*analogs & derivatives/*pharmacology
MH  - *Proton Pump Inhibitors
EDAT- 2001/03/23 10:00
MHDA- 2001/05/25 10:01
CRDT- 2001/03/23 10:00
PHST- 2001/03/23 10:00 [pubmed]
PHST- 2001/05/25 10:01 [medline]
PHST- 2001/03/23 10:00 [entrez]
AID - 10.11150/kansenshogakuzasshi1970.75.137 [doi]
PST - ppublish
SO  - Kansenshogaku Zasshi. 2001 Feb;75(2):137-43. doi: 
      10.11150/kansenshogakuzasshi1970.75.137.