PMID- 11263156
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20140625
VI  - 12
IP  - 8
DP  - 1998 Aug
TI  - [A study of the expression of c-myc onoprotein in laryngeal cancer and different 
      distant adjacent mucosa].
PG  - 353-5
AB  - Using citric-LSAB-microwave immunohistochemical technique, the expression of 
      c-myc was studied in different regions of larynx including laryngeal squamous 
      cell carcinoma (LSCC), border area, adjacent mucosa which was 0.5, 1.0, 1.5 and 
      2.0 cm away from cancer 30 cases and four cases of normal laryngeal mucosa. The 
      results showed that over-expression of c-myc in LSCC was found in 29 of 30 
      (96.7%), which was higher than that in normal laryngeal mucosa (P < 0.01). A 
      significant different expression of c-myc can be seen at the regions of 2.0 and 
      1.5 cm distant from the tumor (P < 0.05). The expression of c-myc increased as 
      tissue progressed in sequence from normal mucosa, adjacent mucosa to carcinoma. 
      The c-myc expression did not correlate with site of tumor, stage and histological 
      grade (P > 0.05). The results indicate that over-expression of c-myc is involved 
      in genesis of LSCC, and may be an early event in the development of human 
      squamous-cell carcinoma of the larynx. The tissue adjacent to the tumor may have 
      a potential malignancy.
FAU - Wan, B
AU  - Wan B
AD  - Department of Otolaryngology, People's Hospital, Henan Province, Zhengzhou 
      450003.
FAU - Dong, M
AU  - Dong M
FAU - Qin, Z
AU  - Qin Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/genetics/*metabolism
MH  - Female
MH  - Gene Expression
MH  - *Genes, myc
MH  - Humans
MH  - Laryngeal Mucosa/metabolism
MH  - Laryngeal Neoplasms/genetics/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-myc/*biosynthesis
EDAT- 2001/03/27 10:00
MHDA- 2001/05/01 10:01
CRDT- 2001/03/27 10:00
PHST- 2001/03/27 10:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/03/27 10:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 1998 Aug;12(8):353-5.