PMID- 11263337 OWN - NLM STAT- MEDLINE DCOM- 20010412 LR - 20061115 IS - 0253-2727 (Print) IS - 0253-2727 (Linking) VI - 19 IP - 11 DP - 1998 Nov TI - [Studies of tumor necrosis factor-alpha and red cell immunity state in multiple myeloma]. PG - 563-5 AB - OBJECTIVE: To explore factors in the pathogenesis of multiple myeloma (MM). METHODS: The plasma level of tumor necrosis factor-alpha (TNF alpha) was measured by immunoassay in 21 MM patients, and red cell immunologic function was assayed in 16 patients. RESULTS: There was no difference in TNF alpha levels among patients with either fulminant MM or stable MM and normal controls. The rosette formation rate of red cell C3 bR and red cell immune complex was significantly lower in MM patients than in the controls. CONCLUSION: MM patients might have impaired monocyte-phagocyte system and red cell immune function. FAU - Huang, Z AU - Huang Z AD - Department of Hematology, Chaoyang Hospital, Capital Medical University, Beijing 100020. FAU - Chen, S AU - Chen S LA - chi PT - English Abstract PT - Journal Article PL - China TA - Zhonghua Xue Ye Xue Za Zhi JT - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi JID - 8212398 RN - 0 (Antigen-Antibody Complex) RN - 0 (Receptors, Complement 3b) RN - 0 (Tumor Necrosis Factor-alpha) SB - IM MH - Adult MH - Aged MH - Antigen-Antibody Complex/immunology MH - Erythrocytes/*immunology MH - Female MH - Humans MH - Male MH - Middle Aged MH - Multiple Myeloma/blood/*immunology MH - Receptors, Complement 3b/*immunology MH - Rosette Formation MH - Tumor Necrosis Factor-alpha/*metabolism EDAT- 2001/03/27 10:00 MHDA- 2001/04/17 10:01 CRDT- 2001/03/27 10:00 PHST- 2001/03/27 10:00 [pubmed] PHST- 2001/04/17 10:01 [medline] PHST- 2001/03/27 10:00 [entrez] PST - ppublish SO - Zhonghua Xue Ye Xue Za Zhi. 1998 Nov;19(11):563-5.