PMID- 11264321
OWN - NLM
STAT- MEDLINE
DCOM- 20010628
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 21
IP  - 7
DP  - 2001 Apr 1
TI  - Sex difference and steroid modulation of pheromone-induced immediate early genes 
      in the two zones of the mouse accessory olfactory system.
PG  - 2474-80
AB  - Two anatomically and neurochemically distinct zones within the vomeronasal organ 
      (VNO) and accessory olfactory bulb (AOB) have been identified that are 
      responsible for the detection of pheromones. Using markers to distinguish between 
      apical and basal neurons of the VNO neuroepithelium and rostral versus caudal AOB 
      glomeruli, we examined immediate early gene immunoreactivity (IEG-IR) in 
      gonadectomized, steroid-treated mice in response to pheromones of male and female 
      conspecifics. After exposure of estradiol-treated females to soiled male bedding, 
      more VNO neurons in the basal than the apical layer exhibited IEG-IR compared 
      with VNO neurons of estradiol-treated males. Conversely, whereas soiled female 
      bedding failed to induce IEG-IR in VNO neurons of estradiol-treated males or 
      females, both apical and basal neurons were activated in testosterone-treated 
      males. Male and female pheromones also activated mitral and granule cells in the 
      AOBs of all subjects, but responses to different pheromones were distributed 
      across the boundary of the rostral and caudal regions. These data show that 
      differences in the response of males and females to the same pheromonal stimulus 
      are found in the sensory neurons of the VNO. We propose that centrifugal, 
      noradrenergic inputs to VNO neurons, which may differ in the two sexes and 
      respond differently to adult sex steroids, modulate sensitivity to pheromonal 
      stimulation.
FAU - Halem, H A
AU  - Halem HA
AD  - Department of Biology, Boston University, Boston, Massachusetts 02215, USA.
FAU - Baum, M J
AU  - Baum MJ
FAU - Cherry, J A
AU  - Cherry JA
LA  - eng
GR  - MH59200/MH/NIMH NIH HHS/United States
GR  - R01 MH059200/MH/NIMH NIH HHS/United States
GR  - T32 HD007387/HD/NICHD NIH HHS/United States
GR  - DC03019/DC/NIDCD NIH HHS/United States
GR  - T32 HD07387/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Pheromones)
RN  - 4TI98Z838E (Estradiol)
SB  - IM
MH  - Animals
MH  - Estradiol/administration & dosage
MH  - Female
MH  - Genes, Immediate-Early/*physiology
MH  - Male
MH  - Mice
MH  - Neurons/*physiology
MH  - Olfactory Bulb/*physiology
MH  - Pheromones/*physiology
MH  - *Sex Characteristics
PMC - PMC6762392
EDAT- 2001/03/27 10:00
MHDA- 2001/06/29 10:01
PMCR- 2001/10/01
CRDT- 2001/03/27 10:00
PHST- 2001/03/27 10:00 [pubmed]
PHST- 2001/06/29 10:01 [medline]
PHST- 2001/03/27 10:00 [entrez]
PHST- 2001/10/01 00:00 [pmc-release]
AID - 21/7/2474 [pii]
AID - 5122 [pii]
AID - 10.1523/JNEUROSCI.21-07-02474.2001 [doi]
PST - ppublish
SO  - J Neurosci. 2001 Apr 1;21(7):2474-80. doi: 10.1523/JNEUROSCI.21-07-02474.2001.