PMID- 11264322
OWN - NLM
STAT- MEDLINE
DCOM- 20010628
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 21
IP  - 7
DP  - 2001 Apr 1
TI  - Olfactory fingerprints for major histocompatibility complex-determined body 
      odors.
PG  - 2481-7
AB  - Recognition of individual body odors is analogous to human face recognition in 
      that it provides information about identity. Individual body odors determined by 
      differences at the major histocompatibility complex (MHC or H-2) have been shown 
      to influence mate choice, pregnancy block, and maternal behavior in mice. 
      Unfortunately, the mechanism and extent of the main olfactory bulb (MOB) and 
      accessory olfactory bulb (AOB) involvement in the discrimination of animals 
      according to H-2-type has remained ambiguous. Here we study the neuronal 
      activation patterns evoked in the MOB in different individuals on exposure to 
      these complex, biologically meaningful sensory stimuli. We demonstrate that body 
      odors from H-2 disparate mice evoke overlapping but distinct maps of neuronal 
      activation in the MOB. The spatial patterns of odor-evoked activity are 
      sufficient to be used like fingerprints to predict H-2 identity using a novel 
      computer algorithm. These results provide functional evidence for discrimination 
      of H-2-determined body odors in the MOB, but do not preclude a role for the AOB. 
      These data further our understanding of the neural strategies used to decode 
      socially relevant odors.
FAU - Schaefer, M L
AU  - Schaefer ML
AD  - Neuroscience Program, Rocky Mountain Taste and Smell Center, Department of 
      Cellular and Structural Biology, University of Colorado Health Sciences Center, 
      Denver, Colorado 80262, USA.
FAU - Young, D A
AU  - Young DA
FAU - Restrepo, D
AU  - Restrepo D
LA  - eng
GR  - F31 MH012438/MH/NIMH NIH HHS/United States
GR  - R01 DC000566/DC/NIDCD NIH HHS/United States
GR  - MH12438/MH/NIMH NIH HHS/United States
GR  - DC00566/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Algorithms
MH  - Animals
MH  - Brain Mapping
MH  - Major Histocompatibility Complex/*physiology
MH  - Mice
MH  - Neurons/physiology
MH  - *Odorants
MH  - Olfactory Bulb/*physiology
PMC - PMC6762408
EDAT- 2001/03/27 10:00
MHDA- 2001/06/29 10:01
PMCR- 2001/10/01
CRDT- 2001/03/27 10:00
PHST- 2001/03/27 10:00 [pubmed]
PHST- 2001/06/29 10:01 [medline]
PHST- 2001/03/27 10:00 [entrez]
PHST- 2001/10/01 00:00 [pmc-release]
AID - 21/7/2481 [pii]
AID - 5119 [pii]
AID - 10.1523/JNEUROSCI.21-07-02481.2001 [doi]
PST - ppublish
SO  - J Neurosci. 2001 Apr 1;21(7):2481-7. doi: 10.1523/JNEUROSCI.21-07-02481.2001.