PMID- 11264453
OWN - NLM
STAT- MEDLINE
DCOM- 20010614
LR  - 20131121
IS  - 0362-1642 (Print)
IS  - 0362-1642 (Linking)
VI  - 41
DP  - 2001
TI  - Phenobarbital response elements of cytochrome P450 genes and nuclear receptors.
PG  - 123-43
AB  - Phenobarbital (PB) response elements are composed of various nuclear receptor 
      (NR)-binding sites. A 51-bp distal element PB-responsive enhancer module (PBREM) 
      conserved in the PB-inducible CYP2B genes contains two NR-binding direct repeat 
      (DR)-4 motifs. Responding to PB exposure in liver, the NR constitutive active 
      receptor (CAR) translocates to the nucleus, forms a dimer with the retinoid X 
      receptor (RXR), and activates PBREM via binding to DR-4 motifs. For CYP3A genes, 
      a common NR site [DR-3 or everted repeat (ER)-6] is present in proximal promoter 
      regions. In addition, the distal element called the xenobiotic responsive module 
      (XREM) is found in human CYP3A4 genes, which contain both DR-3 and ER-6 motifs. 
      Pregnane X receptor (PXR) could bind to all of these sites and, upon PB 
      induction, a PXR:RXR heterodimer could transactivate XREM. These response 
      elements and NRs are functionally versatile, and capable of responding to 
      distinct but overlapping groups of xenochemicals.
FAU - Sueyoshi, T
AU  - Sueyoshi T
AD  - Pharmacogenetics Section, Laboratory of Reproductive and Developmental 
      Toxicology, National Institute of Environmental Health Sciences, National 
      Institutes of Health, Research Triangle Park, North Carolina 27709, USA.
FAU - Negishi, M
AU  - Negishi M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Pharmacol Toxicol
JT  - Annual review of pharmacology and toxicology
JID - 7607088
RN  - 0 (Hypnotics and Sedatives)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - YQE403BP4D (Phenobarbital)
SB  - IM
MH  - Animals
MH  - Cytochrome P-450 Enzyme System/drug effects/*genetics
MH  - Gene Expression Regulation, Enzymologic/drug effects
MH  - Humans
MH  - Hypnotics and Sedatives/*pharmacology
MH  - Phenobarbital/*pharmacology
MH  - Receptors, Cytoplasmic and Nuclear/*drug effects
MH  - Response Elements/*drug effects
RF  - 100
EDAT- 2001/03/27 10:00
MHDA- 2001/06/23 10:01
CRDT- 2001/03/27 10:00
PHST- 2001/03/27 10:00 [pubmed]
PHST- 2001/06/23 10:01 [medline]
PHST- 2001/03/27 10:00 [entrez]
AID - 41/1/123 [pii]
AID - 10.1146/annurev.pharmtox.41.1.123 [doi]
PST - ppublish
SO  - Annu Rev Pharmacol Toxicol. 2001;41:123-43. doi: 
      10.1146/annurev.pharmtox.41.1.123.