PMID- 11268341
OWN - NLM
STAT- MEDLINE
DCOM- 20010419
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 917
DP  - 2000
TI  - Not all peripheral immune stimuli that activate the HPA axis induce 
      proinflammatory cytokine gene expression in the hypothalamus.
PG  - 169-74
AB  - Administration of low doses of lipopolysaccharide (LPS) that do not disrupt the 
      blood-brain barrier (BBB) results in the expression of interleukin-1 beta (IL-1 
      beta), IL-6, and tumor necrosis factor-alpha (TNF alpha) in the hypothalamus in 
      parallel to stimulation of the hypothalamus-pituitary-adrenal (HPA) axis. This 
      endocrine response is triggered by peripheral cytokines, and we recently obtained 
      evidence that brain-borne IL-1 contributes to its maintenance. LPS preferentially 
      stimulates cells of the macrophage lineage and B lymphocytes. The possibility 
      that primarily stimulation of other types of peripheral immune cells also results 
      in the expression of proinflammatory cytokines in the brain and in the activation 
      of the HPA axis was investigated. Our results showed that, in contrast to LPS, 
      administration of the superantigen staphylococcal enterotoxin B (SEB), which 
      stimulates T cells by binding to appropriate V beta domains of the T-cell 
      receptor, did not result in induction of IL-1 beta, IL-6, and TNF alpha 
      expression in the hypothalamus. Furthermore, although IL-2 transcripts in the 
      spleen were highly increased, expression of this gene was not detected in the 
      brain. However, as with LPS, SEB administration also results in elevated levels 
      of glucocorticoids in blood. Therefore, our data suggest that increased 
      expression of proinflammatory cytokines in the brain is not a necessary step in 
      the stimulation of the HPA axis by SEB.
FAU - Del Rey, A
AU  - Del Rey A
AD  - Division of Immunophysiology, Institute of Physiology, Philipps-University, 
      Deutschhausstrasse 2, 35037 Marburg, Germany.
FAU - Randolf, A
AU  - Randolf A
FAU - Pitossi, F
AU  - Pitossi F
FAU - Rogausch, H
AU  - Rogausch H
FAU - Besedovsky, H O
AU  - Besedovsky HO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Cytokines/biosynthesis/genetics/*immunology
MH  - Gene Expression Regulation/immunology
MH  - Hypothalamo-Hypophyseal System/*immunology
MH  - Hypothalamus/immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Neuroimmunomodulation
MH  - Pituitary-Adrenal System/*immunology
EDAT- 2001/03/28 10:00
MHDA- 2001/04/21 10:01
CRDT- 2001/03/28 10:00
PHST- 2001/03/28 10:00 [pubmed]
PHST- 2001/04/21 10:01 [medline]
PHST- 2001/03/28 10:00 [entrez]
AID - 10.1111/j.1749-6632.2000.tb05381.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2000;917:169-74. doi: 10.1111/j.1749-6632.2000.tb05381.x.