PMID- 11269929
OWN - NLM
STAT- MEDLINE
DCOM- 20010426
LR  - 20131121
IS  - 1566-0702 (Print)
IS  - 1566-0702 (Linking)
VI  - 86
IP  - 1-2
DP  - 2000 Dec 28
TI  - Evidence that nerve growth factor promotes the recovery of peripheral neuropathy 
      induced in mice by cisplatin: behavioral, structural and biochemical analysis.
PG  - 84-93
AB  - In this study we investigate the neurotoxic action of Cisplatin (6 micrograms/g 
      body weight for 5 treatment cycles during 15 weeks with a total dose of 30 
      micrograms/g), an antitumor drug, and its effect on the level of nerve growth 
      factor (NGF) and brain-derived neurotrophic factor (BDNF) in peripheral tissues. 
      We found that Cisplatin in adult rodents impairs peripheral sensory function and 
      both sympathetic and sensory peripheral innervation as shown by the hot-plate 
      response, catecholamine distribution and substance P immunoreactivity 
      respectively. These changes are associated with decreased NGF in intestine, paws, 
      and bladder while NGF increased in the spinal cord. Also BDNF decreased in 
      bladder and paws and increased in spinal cord and intestine. To further 
      investigate the role of NGF in the pathogenesis of Cisplatin-induced peripheral 
      neuropathies a group of animals was injected with NGF (1 microgram/g every 4 days 
      for 4 times) following Cisplatin treatment and evaluated for sensory function, 
      sympathetic and sensory innervation and BDNF levels. Data demonstrated that 
      exogenous NGF administration is able to restore biochemical, structural and 
      functional changes induced by Cisplatin. These findings suggest that the 
      reduction of NGF availability could be a cause of Cisplatin-induced peripheral 
      neuropathies and that NGF exogenous administration could prevent or reduce 
      Cisplatin neurotoxicity also in cancer patients, reducing the side effects of 
      chemotherapy.
FAU - Aloe, L
AU  - Aloe L
AD  - Institute of Neurobiology, Consiglio Nazionale delle Ricerche, Viale Marx, 15/43, 
      00137 Rome, Italy. aloe@in.rm.cnr.it
FAU - Manni, L
AU  - Manni L
FAU - Properzi, F
AU  - Properzi F
FAU - De Santis, S
AU  - De Santis S
FAU - Fiore, M
AU  - Fiore M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Auton Neurosci
JT  - Autonomic neuroscience : basic & clinical
JID - 100909359
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 33507-63-0 (Substance P)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cisplatin/*toxicity
MH  - Male
MH  - Mice
MH  - Motor Activity/drug effects/physiology
MH  - Nerve Growth Factor/*metabolism/*pharmacology
MH  - Pain Measurement
MH  - Peripheral Nerves/*drug effects/metabolism/physiopathology
MH  - Peripheral Nervous System Diseases/chemically induced/*drug 
      therapy/physiopathology
MH  - Reaction Time/drug effects/physiology
MH  - Substance P/metabolism
MH  - Sympathetic Fibers, Postganglionic/drug effects/pathology
EDAT- 2001/03/29 10:00
MHDA- 2001/05/01 10:01
CRDT- 2001/03/29 10:00
PHST- 2001/03/29 10:00 [pubmed]
PHST- 2001/05/01 10:01 [medline]
PHST- 2001/03/29 10:00 [entrez]
AID - S1566-0702(00)00247-2 [pii]
AID - 10.1016/S1566-0702(00)00247-2 [doi]
PST - ppublish
SO  - Auton Neurosci. 2000 Dec 28;86(1-2):84-93. doi: 10.1016/S1566-0702(00)00247-2.