PMID- 1127
OWN - NLM
STAT- MEDLINE
DCOM- 19760315
LR  - 20190902
IS  - 0006-5242 (Print)
IS  - 0006-5242 (Linking)
VI  - 31
IP  - 6
DP  - 1975 Dec
TI  - Bone marrow transplantation for aplastic anaemia from a HL-A and MLC-identical 
      unrelated donor.
PG  - 347-54
AB  - Bone-marrow transplantation (BMT) from an unrelated, HL-A-phenotype-identical, 
      MLC-negative donor was performed in a 31 year old woman with severe longlasting 
      aplastic anemia. In vitro assays failed to demonstrate humoral or cellular 
      sensitization of the recipient against donor-type antigens. Following 
      conditioning with cyclophosphamide, prompt but only transient engraftment of the 
      transplant occurred accompanied by signs of mild graft-versus-host-disease (GVHD) 
      of the liver. The results of a second bone marrow transplantation from the same 
      donor cannot be evaluated due to early death of the recipient. It is concluded 
      that bone marrow from unrelated, HL-A and MLC-identical donors may engraft 
      without severe GVHD. Rejection of the graft in our patient may have been related 
      to greater antigenic differences that can be expected to exist between HL-A and 
      MLC-identical unrelated individuals than between HL-A and MLC-identical siblings. 
      However, insufficient preparative immunosuppression with cyclophosphamide due to 
      severe hepatic hemosiderosis appears equally likely as the cause of graft 
      rejection. The possibly increased risk of graft rejection or severe GVHD should 
      not preclude the use of unrelated HL-A and MLC-identical marrow donors, when 
      histocompatible sibling donors are not available; but more potent 
      immunosuppressive regimens than the cyclophosphamide protocol may be necessary to 
      ensure permanent engraftment.
FAU - Lohrmann, H P
AU  - Lohrmann HP
FAU - Dietrich, M
AU  - Dietrich M
FAU - Goldmann, S F
AU  - Goldmann SF
FAU - Kristensen, T
AU  - Kristensen T
FAU - Fliedner, T M
AU  - Fliedner TM
FAU - Abt, C
AU  - Abt C
FAU - Pflieger, H
AU  - Pflieger H
FAU - Flad, H D
AU  - Flad HD
FAU - Kubanek, B
AU  - Kubanek B
FAU - Heimpel, H
AU  - Heimpel H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Germany
TA  - Blut
JT  - Blut
JID - 0173401
RN  - 0 (HLA Antigens)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Adult
MH  - Anemia, Aplastic/immunology/*therapy
MH  - Bone Marrow/immunology
MH  - *Bone Marrow Cells
MH  - *Bone Marrow Transplantation
MH  - Cyclophosphamide/therapeutic use
MH  - Female
MH  - Graft Rejection
MH  - Graft vs Host Reaction/complications
MH  - HLA Antigens
MH  - Hemosiderosis/complications
MH  - Humans
MH  - Liver Diseases/complications
MH  - Lymphocyte Culture Test, Mixed
MH  - Transplantation, Homologous
EDAT- 1975/12/01 00:00
MHDA- 1975/12/01 00:01
CRDT- 1975/12/01 00:00
PHST- 1975/12/01 00:00 [pubmed]
PHST- 1975/12/01 00:01 [medline]
PHST- 1975/12/01 00:00 [entrez]
AID - 10.1007/BF01634000 [doi]
PST - ppublish
SO  - Blut. 1975 Dec;31(6):347-54. doi: 10.1007/BF01634000.