PMID- 11270642
OWN - NLM
STAT- MEDLINE
DCOM- 20010607
LR  - 20231213
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 45
IP  - 3
DP  - 2001 Mar
TI  - Polymorphism of human leukocyte antigen-E gene in the Japanese population with or 
      without recurrent abortion.
PG  - 168-73
AB  - PROBLEM: The aim of this study was to investigate the gene frequencies and shared 
      alleles of human leukocyte antigen (HLA)-E gene in Japanese couples with or 
      without recurrent abortion. METHOD OF STUDY: Polymerase chain reaction 
      (PCR)-single strand conformation polymorphism (SSCP) analysis was carried out to 
      detect polymorphism in exon 3 of the HLA-E gene in 30 Japanese couples with 
      recurrent abortion and 38 normal Japanese couples with proven fertility. RESULTS: 
      No point mutation was detected in exon 3 of HLA-E in both recurrent aborters and 
      normal controls. HLA-EG and HLA-ER alleles were detected with frequencies of 
      66.7% and 33.3% in couples with recurrent abortion and 69.2% and 30.8 in normal 
      couples, respectively. The gene frequency of HLA-EG was higher than that of 
      HLA-ER, which is contrary to that found in Caucasian, African-American and 
      Hispanic people but similar to Chinese people. The frequency of each allele was 
      not significantly different between recurrent aborters and normal controls. The 
      number of shared alleles between each couple with recurrent abortion is not 
      significantly different from that with normal controls. CONCLUSION: Allele 
      frequencies of HLA-E were suggested to be different in Asian people from those in 
      other ethnic people. In light of no specific distribution pattern in recurrent 
      aborters, HLA-E polymorphism does not seem to play a role in the pathogenesis of 
      recurrent abortion.
FAU - Kanai, T
AU  - Kanai T
AD  - Department of Obstetrics and Gynecology, Faculty of Medicine, University of 
      Tokyo, Japan.
FAU - Fujii, T
AU  - Fujii T
FAU - Keicho, N
AU  - Keicho N
FAU - Tokunaga, K
AU  - Tokunaga K
FAU - Yamashita, T
AU  - Yamashita T
FAU - Hyodo, H
AU  - Hyodo H
FAU - Miki, A
AU  - Miki A
FAU - Unno, N
AU  - Unno N
FAU - Kozuma, S
AU  - Kozuma S
FAU - Taketani, Y
AU  - Taketani Y
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Abortion, Habitual/*genetics
MH  - Alleles
MH  - Asian People/*genetics
MH  - Female
MH  - Gene Frequency
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Japan
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single-Stranded Conformational
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - HLA-E Antigens
EDAT- 2001/03/29 10:00
MHDA- 2001/06/08 10:01
CRDT- 2001/03/29 10:00
PHST- 2001/03/29 10:00 [pubmed]
PHST- 2001/06/08 10:01 [medline]
PHST- 2001/03/29 10:00 [entrez]
AID - 10.1111/j.8755-8920.2001.450308.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2001 Mar;45(3):168-73. doi: 
      10.1111/j.8755-8920.2001.450308.x.