PMID- 11275534
OWN - NLM
STAT- MEDLINE
DCOM- 20010521
LR  - 20190921
IS  - 1388-2457 (Print)
IS  - 1388-2457 (Linking)
VI  - 112
IP  - 4
DP  - 2001 Apr
TI  - Interhemispheric interaction between the hand motor areas in patients with 
      cortical myoclonus.
PG  - 623-6
AB  - OBJECTIVE: To study interhemispheric interaction between the hand motor areas of 
      both hemispheres through the corpus callosum in myoclonus epilepsy. SUBJECTS: 
      Five patients with benign myoclonus epilepsy and ten age matched normal 
      volunteers. METHODS: We studied effects of a medially directed conditioning 
      stimulus over the right hand motor area on responses in the right first dorsal 
      interosseous muscle to a posteriorly directed test stimulus over the left hand 
      motor area. RESULTS: In normal subjects, inhibition was evoked at interstimulus 
      intervals (ISIs) of 8-20ms (late inhibition). In contrast, facilitation occurred 
      in patients at ISIs of 4-6ms (early facilitation) with no late inhibition. 
      CONCLUSIONS: The lack of late inhibition in the patients is consistent with the 
      idea that cortical inhibitory interneurones are affected in myoclonus epilepsy. 
      We propose that this releases interhemispheric facilitation from powerful 
      surround inhibition. The consequence is a predominant early facilitation between 
      the hemispheres in patients with myoclonus epilepsy.
FAU - Hanajima, R
AU  - Hanajima R
AD  - Department of Neurology, Division of Neuroscience, Graduate School of Medicine, 
      University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
FAU - Ugawa, Y
AU  - Ugawa Y
FAU - Okabe, S
AU  - Okabe S
FAU - Yuasa, K
AU  - Yuasa K
FAU - Shiio, Y
AU  - Shiio Y
FAU - Iwata, N K
AU  - Iwata NK
FAU - Kanazawa, I
AU  - Kanazawa I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Neurophysiol
JT  - Clinical neurophysiology : official journal of the International Federation of 
      Clinical Neurophysiology
JID - 100883319
SB  - IM
MH  - Corpus Callosum/physiopathology
MH  - Electric Stimulation/methods
MH  - Electromyography
MH  - Epilepsies, Myoclonic/*physiopathology
MH  - Hand/innervation/physiology
MH  - Humans
MH  - Magnetics/instrumentation
MH  - Matched-Pair Analysis
MH  - Motor Cortex/*physiopathology
MH  - Movement/*physiology
MH  - Muscle, Skeletal/*physiopathology
MH  - Neural Inhibition
MH  - Time Factors
EDAT- 2001/03/29 10:00
MHDA- 2001/05/25 10:01
CRDT- 2001/03/29 10:00
PHST- 2001/03/29 10:00 [pubmed]
PHST- 2001/05/25 10:01 [medline]
PHST- 2001/03/29 10:00 [entrez]
AID - S1388-2457(01)00477-1 [pii]
AID - 10.1016/s1388-2457(01)00477-1 [doi]
PST - ppublish
SO  - Clin Neurophysiol. 2001 Apr;112(4):623-6. doi: 10.1016/s1388-2457(01)00477-1.