PMID- 11275631
OWN - NLM
STAT- MEDLINE
DCOM- 20010927
LR  - 20171101
IS  - 0250-8095 (Print)
IS  - 0250-8095 (Linking)
VI  - 21
IP  - 1
DP  - 2001 Jan-Feb
TI  - Monocyte-related determinants of inflammation in patients on peritoneal dialysis.
PG  - 40-6
AB  - AIMS: We studied markers of monocyte activation, i.e., the cell surface 
      expression of CD11b and CD62L, and the serum concentrations of monocyte 
      chemotactic protein 1 (MCP-1; a monocyte-specific chemoattractant) and soluble 
      vascular cell adhesion molecule 1 (sVCAM-1; an adhesion molecule involved in 
      monocyte recruitment) in 20 patients on peritoneal dialysis (PD), in 25 patients 
      with chronic renal insufficiency, and in 27 healthy subjects. RESULTS: Monocytes 
      obtained from the peripheral blood of PD patients had a significantly higher 
      expression of CD62L (p = 0.02) as compared with monocytes from healthy subjects 
      and a lower CD11b/CD18 expression as compared with monocytes collected from 
      healthy subjects (p < 0.001) and from patients with renal insufficiency (p < 
      0.001). Monocytes from PD patients had, however, the capacity to increase the 
      expression of CD11b following stimulation with a potent chemotactic factor. The 
      serum concentrations of MCP-1 and sVCAM-1 were higher in PD patients (575 +/- 51 
      and 1,517 +/- 89 ng/ml) than in healthy subjects (225 +/- 17 and 668 +/- 64 
      ng/ml, respectively; p < 0.001 for both comparisons). There was a correlation 
      between the levels of sVCAM-1 and MCP-1 (r = 0.48, p < 0.05) in patients on PD, 
      but neither correlated with the monocyte expression of CD11b/CD18 or CD62L. The 
      concentration of C-reactive protein was higher in patients on PD as compared with 
      healthy subjects and correlated significantly with the concentration of sVCAM-1 
      (r = 0.63, p < 0.01). CONCLUSIONS: Monocytes in the peripheral circulation of 
      patients on PD have a CD62L(high)/CD11b(low) phenotype, indicating that they have 
      not undergone complete differentiation. Patients also have an increase in the 
      systemic chemotactic activity for monocytes in combination with increased levels 
      of sVCAM-1 and C-reactive protein. These inflammatory aberrations may play a 
      pathophysiological role in the response to inflammatory and infectious diseases 
      in patients on PD.
FAU - Jacobson, S H
AU  - Jacobson SH
AD  - Department of Nephrology, Karolinska Hospital, Stockholm, Sweden. 
      stefan.jacobson@ks.se
FAU - Hylander, B
AU  - Hylander B
FAU - Thylen, P
AU  - Thylen P
FAU - Lundahl, J
AU  - Lundahl J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Am J Nephrol
JT  - American journal of nephrology
JID - 8109361
RN  - 0 (Cell Adhesion Molecules)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cell Adhesion Molecules/blood
MH  - Cell Count
MH  - Female
MH  - Humans
MH  - Inflammation/*immunology
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*immunology
MH  - *Peritoneal Dialysis
EDAT- 2001/03/29 10:00
MHDA- 2001/09/28 10:01
CRDT- 2001/03/29 10:00
PHST- 2001/03/29 10:00 [pubmed]
PHST- 2001/09/28 10:01 [medline]
PHST- 2001/03/29 10:00 [entrez]
AID - 46217 [pii]
AID - 10.1159/000046217 [doi]
PST - ppublish
SO  - Am J Nephrol. 2001 Jan-Feb;21(1):40-6. doi: 10.1159/000046217.