PMID- 11278104
OWN - NLM
STAT- MEDLINE
DCOM- 20010614
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 302
IP  - 1
DP  - 2001 Apr 13
TI  - Effect of hypergravity on the mouse basal expression of NGF and BDNF in the 
      retina, visual cortex and geniculate nucleus: correlative aspects with NPY 
      immunoreactivity.
PG  - 29-32
AB  - We investigated the effect of hypergravitation on Nerve growth factor (NGF) and 
      Brain-derived-neurotrophic factor (BDNF) expression in the visual cortex, 
      geniculate nucleus (GN), and retina of adult male mice. The results showed that 
      altered gravity causes an increase in NGF and BDNF in the visual cortex and GN 
      which resulted to be associated with an up-regulation of cells immunoreactive to 
      neuropeptide Y (NPY) in the visual cortex and GN. We also found a decrease in 
      NGF, BDNF, and NPY in the mouse retina exposed to hypergravity. These findings 
      suggest that alteration in gravitational environment differentially affects local 
      neurotrophic factors and NPY expression. The possible functional significance of 
      these observations is discussed.
FAU - Aloe, L
AU  - Aloe L
AD  - Istituto di Neurobiologia, Consiglio Nazionale delle Ricerche, Viale Carlo Marx 
      15/43, I-00137, Rome, Italy. aloe@in.rm.cnr.it
FAU - Fiore, M
AU  - Fiore M
FAU - Santucci, D
AU  - Santucci D
FAU - Amendola, T
AU  - Amendola T
FAU - Antonelli, A
AU  - Antonelli A
FAU - Francia, N
AU  - Francia N
FAU - Corazzi, G
AU  - Corazzi G
FAU - Alleva, E
AU  - Alleva E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuropeptide Y)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Geniculate Bodies/*metabolism
MH  - *Hypergravity
MH  - Male
MH  - Mice
MH  - Nerve Growth Factor/*metabolism
MH  - Neuropeptide Y/*metabolism
MH  - Retina/*metabolism
MH  - Visual Cortex/*metabolism
EDAT- 2001/03/30 10:00
MHDA- 2001/06/15 10:01
CRDT- 2001/03/30 10:00
PHST- 2001/03/30 10:00 [pubmed]
PHST- 2001/06/15 10:01 [medline]
PHST- 2001/03/30 10:00 [entrez]
AID - S0304394001016482 [pii]
AID - 10.1016/s0304-3940(01)01648-2 [doi]
PST - ppublish
SO  - Neurosci Lett. 2001 Apr 13;302(1):29-32. doi: 10.1016/s0304-3940(01)01648-2.