PMID- 11279300
OWN - NLM
STAT- MEDLINE
DCOM- 20010705
LR  - 20231213
IS  - 1360-9947 (Print)
IS  - 1360-9947 (Linking)
VI  - 7
IP  - 4
DP  - 2001 Apr
TI  - The HLA-G genotype is potentially associated with idiopathic recurrent 
      spontaneous abortion.
PG  - 373-8
AB  - The causes for recurrent spontaneous abortion (RSA) remain unknown in a large 
      proportion of the cases. Human leukocyte antigen (HLA)-G and HLA-E are expressed 
      on invasive trophoblast cells, and are supposed to confer to materno-fetal 
      tolerance. A total of 14 different nucleotide sequences have been described for 
      HLA-G, including one dysfunctional null allele (HLA-G*0105N), while five 
      different sequences have been described for HLA-E. In this study, 78 RSA couples 
      and 52 fertile controls were typed for HLA-G and HLA-E by direct sequencing or 
      single strand conformational polymorphism (SSCP) respectively. The overall 
      analysis showed no significant difference in allele frequencies for either HLA-G 
      or HLA-E between the two groups. However, HLA-G allele frequencies in women who 
      had suffered from five or more RSA differed significantly from fertile controls 
      (P: = 0.001), and from women who had undergone three or four RSA (P: = 0.027). 
      Detailed analysis demonstrated a significant increase in the proportion of the 
      HLA-G alleles *01013 and *0105N in the whole group of RSA women compared with 
      fertile controls (P: = 0.007). When studying the prognostic value of HLA 
      genotyping for pregnancy outcome (n = 41), 31 patients (76%) gave birth to a 
      living child without performing immunotherapy. Seven out of 10 (70%) couples 
      suffering from a further RSA carried the HLA-G*01013 or *0105N allele, compared 
      with 10 out 31 (32%) couples giving birth (P: = 0.06). This study suggests that 
      the HLA-G genotype may be a contributing factor in RSA.
FAU - Pfeiffer, K A
AU  - Pfeiffer KA
AD  - Department of Obstetrics and Gynecology, University of Bonn, Sigmund Freud 
      Strasse 25, 53105 Bonn, Germany. k.pfeiffer@uni-bonn.de
FAU - Fimmers, R
AU  - Fimmers R
FAU - Engels, G
AU  - Engels G
FAU - van der Ven, H
AU  - van der Ven H
FAU - van der Ven, K
AU  - van der Ven K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mol Hum Reprod
JT  - Molecular human reproduction
JID - 9513710
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Abortion, Habitual/*genetics/immunology
MH  - Adult
MH  - Female
MH  - Genotype
MH  - HLA Antigens/classification/*genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/classification/*genetics
MH  - Histocompatibility Testing
MH  - Humans
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single-Stranded Conformational
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - HLA-E Antigens
EDAT- 2001/03/30 10:00
MHDA- 2001/07/06 10:01
CRDT- 2001/03/30 10:00
PHST- 2001/03/30 10:00 [pubmed]
PHST- 2001/07/06 10:01 [medline]
PHST- 2001/03/30 10:00 [entrez]
AID - 10.1093/molehr/7.4.373 [doi]
PST - ppublish
SO  - Mol Hum Reprod. 2001 Apr;7(4):373-8. doi: 10.1093/molehr/7.4.373.