PMID- 11281299
OWN - NLM
STAT- MEDLINE
DCOM- 20010719
LR  - 20191025
IS  - 0954-6928 (Print)
IS  - 0954-6928 (Linking)
VI  - 12
IP  - 2
DP  - 2001 Mar
TI  - Role of cytokines in the pathogenesis of restenosis after percutaneous 
      transluminal coronary angioplasty.
PG  - 107-13
AB  - BACKGROUND: Inflammatory cytokines play an important role in mediating 
      inflammatory/proliferative responses including atherosclerosis. However, their 
      role in the pathogenesis of restenosis after percutaneous transluminal coronary 
      angioplasty (PTCA) remains to be clarified. OBJECTIVE: To determine plasma levels 
      of inflammatory cytokines as well as cytokine-generation capacities of monocytes 
      before PTCA and after the follow-up period. METHODS: Plasma levels of cytokines 
      in 34 consecutive patients before and 3-6 months after PTCA were measured by 
      enzyme-linked immunosorbent assay. We measured the plasma levels of 
      macrophage-colony-stimulating factor (MCSF) and transforming growth factor-beta. 
      Cytokine-generation capacities of monocytes were also measured by a whole-blood 
      induction method with lipopolysaccharide. The levels of cytokines measured for 
      assessment of the capacities included those of interleukin-1alpha, 
      interleukin-1beta, interleukin-6, granulocyte-colony-stimulating factor, tumor 
      necrosis factor-alpha and interferon-gamma. RESULTS: Plasma levels of MCSF in 
      patients without restenosis (n = 20) decreased significantly (from 1460+/-138 
      microg/ml before PTCA to 1039+/-125 microg/ml after the follow-up period, P < 
      0.01), whereas those in patients with restenosis (n = 14) increased significantly 
      (from 1107+/-105 microg/ml before PTCA to 1039+/-125 microg/ml after the 
      follow-up period, P < 0.05). We noted a positive correlation between the increase 
      in plasma levels of MCSF and the extent of loss of lumen by restenosis. 
      Cytokine-generation capacities of monocytes for interleukin-1alpha and 
      interleukin-1beta of patients with restenosis significantly increased but those 
      of patients without restenosis did not. Furthermore, plasma levels of C-reactive 
      protein decreased significantly only in patients without restenosis after the 
      follow-up period. CONCLUSIONS: These results suggest that inflammatory changes 
      mediated by cytokines may be involved in the pathogenesis of restenosis after 
      PTCA.
FAU - Tashiro, H
AU  - Tashiro H
AD  - Division of Cardiology, St Mary's Hospital, Kurume, Japan.
FAU - Shimokawa, H
AU  - Shimokawa H
FAU - Sadamatsu, K
AU  - Sadamatsu K
FAU - Aoki, T
AU  - Aoki T
FAU - Yamamoto, K
AU  - Yamamoto K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Coron Artery Dis
JT  - Coronary artery disease
JID - 9011445
RN  - 0 (Cytokines)
RN  - 0 (Transforming Growth Factor beta)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - *Angioplasty, Balloon, Coronary
MH  - C-Reactive Protein/metabolism
MH  - Coronary Disease/*etiology/*therapy
MH  - Cytokines/*physiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Macrophage Colony-Stimulating Factor/blood
MH  - Male
MH  - Monocytes/metabolism
MH  - Recurrence
MH  - Time Factors
MH  - Transforming Growth Factor beta/blood
EDAT- 2001/04/03 10:00
MHDA- 2001/07/20 10:01
CRDT- 2001/04/03 10:00
PHST- 2001/04/03 10:00 [pubmed]
PHST- 2001/07/20 10:01 [medline]
PHST- 2001/04/03 10:00 [entrez]
AID - 10.1097/00019501-200103000-00004 [doi]
PST - ppublish
SO  - Coron Artery Dis. 2001 Mar;12(2):107-13. doi: 10.1097/00019501-200103000-00004.